| pubmed-article:16419025 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0220806 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0004180 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0577559 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0073633 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0596801 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0008565 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C1709793 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0205352 | lld:lifeskim |
| pubmed-article:16419025 | lifeskim:mentions | umls-concept:C0332324 | lld:lifeskim |
| pubmed-article:16419025 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16419025 | pubmed:dateCreated | 2006-2-7 | lld:pubmed |
| pubmed-article:16419025 | pubmed:abstractText | A sensitive and specific method using liquid chromatography with atmospheric pressure chemical ionization mass spectrometry (LC/APCI-MS) has been developed and validated for the identification and quantification of Ranolazine in rat plasma. A simple liquid-liquid extraction procedure was followed by injection of the extracts onto a C18 column with isocratic elution and detection using a single quadrupole mass spectrometer in selected ion monitoring (SIM) mode. The method was tested using six different batches of blank plasma. Linearity was established for the concentration range 0.02-10.0 microg/mL, with a coefficient of determination (r) of 0.9998 and good back-calculated accuracy and precision. The intra- and inter-day precision (relative standard deviation (RSD) %) was lower than 10%, and accuracy ranged from 85 to 115%. The lower limit of quantification was reproducible at 0.01 microg/mL with 20 microL plasma. The proposed method enables the unambiguous identification and quantification of Ranolazine for pre-clinical and clinical studies. | lld:pubmed |
| pubmed-article:16419025 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16419025 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16419025 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16419025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16419025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16419025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16419025 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16419025 | pubmed:issn | 0951-4198 | lld:pubmed |
| pubmed-article:16419025 | pubmed:author | pubmed-author:SzeS HSH | lld:pubmed |
| pubmed-article:16419025 | pubmed:author | pubmed-author:LuTongT | lld:pubmed |
| pubmed-article:16419025 | pubmed:author | pubmed-author:WangGuang-JiG... | lld:pubmed |
| pubmed-article:16419025 | pubmed:author | pubmed-author:LiangYanY | lld:pubmed |
| pubmed-article:16419025 | pubmed:author | pubmed-author:ChenWei-DongW... | lld:pubmed |
| pubmed-article:16419025 | pubmed:author | pubmed-author:LiuXiao-DongX... | lld:pubmed |
| pubmed-article:16419025 | pubmed:author | pubmed-author:YeXiongX | lld:pubmed |
| pubmed-article:16419025 | pubmed:copyrightInfo | Copyright 2006 John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:16419025 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16419025 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:16419025 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16419025 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16419025 | pubmed:pagination | 523-8 | lld:pubmed |
| pubmed-article:16419025 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:16419025 | pubmed:meshHeading | pubmed-meshheading:16419025... | lld:pubmed |
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| pubmed-article:16419025 | pubmed:meshHeading | pubmed-meshheading:16419025... | lld:pubmed |
| pubmed-article:16419025 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16419025 | pubmed:articleTitle | Simple, sensitive and rapid liquid chromatography/atmospheric pressure chemical ionization mass spectrometric method for the quantitation of Ranolazine in rat plasma. | lld:pubmed |
| pubmed-article:16419025 | pubmed:affiliation | Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China. | lld:pubmed |
| pubmed-article:16419025 | pubmed:publicationType | Journal Article | lld:pubmed |
