| pubmed-article:16415873 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16415873 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:16415873 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:16415873 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16415873 | lifeskim:mentions | umls-concept:C1534866 | lld:lifeskim |
| pubmed-article:16415873 | lifeskim:mentions | umls-concept:C1422014 | lld:lifeskim |
| pubmed-article:16415873 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16415873 | lifeskim:mentions | umls-concept:C0205228 | lld:lifeskim |
| pubmed-article:16415873 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16415873 | pubmed:dateCreated | 2006-1-20 | lld:pubmed |
| pubmed-article:16415873 | pubmed:abstractText | Here we have identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9 (sensors for double-stranded RNA, single-stranded RNA and unmethylated DNA, respectively). The 3d mutation also prevented cross-presentation and diminished major histocompatibility complex class II presentation of exogenous antigen; it also caused hypersusceptibility to infection by mouse cytomegalovirus and other microbes. By positional identification, we found 3d to be a missense allele of Unc93b1, which encodes the 12-membrane-spanning protein UNC-93B, a highly conserved molecule found in the endoplasmic reticulum with multiple paralogs in mammals. Innate responses to nucleic acids and exogenous antigen presentation, which both initiate in endosomes, thus seem to depend on an endoplasmic reticulum-resident protein, which suggests communication between these organellar systems. | lld:pubmed |
| pubmed-article:16415873 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415873 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16415873 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415873 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16415873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415873 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16415873 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16415873 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:LüZ BZB | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:GrinsteinSerg... | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:BeutlerBruceB | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:PortnoyDaniel... | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:WiltshireTimT | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:TabetaKoichiK | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:JanssenEdith... | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:HerskovitsAna... | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:GeorgelPhilip... | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:HoebeKasperK | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:TarantinoLisa... | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:CookeMichaelM | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:MannNavjiwanN | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:GoodeJasonJ | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:CrozatKarineK | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:MuddSuzanneS | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:ShamelLouisL | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:SovathSosathy... | lld:pubmed |
| pubmed-article:16415873 | pubmed:author | pubmed-author:SteinbergBenj... | lld:pubmed |
| pubmed-article:16415873 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16415873 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:16415873 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16415873 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16415873 | pubmed:pagination | 156-64 | lld:pubmed |
| pubmed-article:16415873 | pubmed:dateRevised | 2007-11-8 | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:meshHeading | pubmed-meshheading:16415873... | lld:pubmed |
| pubmed-article:16415873 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16415873 | pubmed:articleTitle | The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. | lld:pubmed |
| pubmed-article:16415873 | pubmed:affiliation | Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA. | lld:pubmed |
| pubmed-article:16415873 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16415873 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16415873 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:16783 | entrezgene:pubmed | pubmed-article:16415873 | lld:entrezgene |
| entrez-gene:54445 | entrezgene:pubmed | pubmed-article:16415873 | lld:entrezgene |
| entrez-gene:81897 | entrezgene:pubmed | pubmed-article:16415873 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16415873 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16415873 | lld:pubmed |
