| pubmed-article:16415088 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16415088 | lifeskim:mentions | umls-concept:C0031516 | lld:lifeskim |
| pubmed-article:16415088 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:16415088 | lifeskim:mentions | umls-concept:C0002864 | lld:lifeskim |
| pubmed-article:16415088 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:16415088 | lifeskim:mentions | umls-concept:C1709060 | lld:lifeskim |
| pubmed-article:16415088 | lifeskim:mentions | umls-concept:C0048752 | lld:lifeskim |
| pubmed-article:16415088 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16415088 | pubmed:dateCreated | 2006-4-18 | lld:pubmed |
| pubmed-article:16415088 | pubmed:abstractText | Androstenol is a steroidal compound belonging to the group of odorous 16-androstenes, first isolated from boar testes and also found in humans. Androstenol has pheromone-like properties in both animals and humans, but the molecular targets of its pheromonal activity are unknown. Androstenol is structurally similar to endogenous A-ring reduced neurosteroids that act as positive modulators of GABA(A) receptors. Here we show that androstenol has neurosteroid-like activity as a GABA(A) receptor modulator. In whole-cell recordings from cerebellar granule cells, androstenol (but not its 3beta-epimer) caused a concentration-dependent enhancement of GABA-activated currents (EC(50), 0.4 microM in cultures; 1.4 microM in slices) and prolonged the duration of spontaneous and miniature inhibitory postsynaptic currents. Androstenol (0.1-1 microM) also potentiated the amplitude of GABA-activated currents in human embryonic kidney 293 cells transfected with recombinant alpha1beta2gamma2 and alpha2beta2gamma2 GABA(A) receptors and, at high concentrations (10-300 microM), directly activated currents in these cells. Systemic administration of androstenol (30-50 mg/kg) caused anxiolytic-like effects in mice in the open-field test and elevated zero-maze and antidepressant-like effects in the forced swim test (5-10 mg/kg). Androstenol, but not its 3beta-epimer, conferred seizure protection in the 6-Hz electroshock and pentylenetetrazol models (ED(50) values, 21.9 and 48.9 mg/kg, respectively). The various actions of androstenol in the whole-animal models are consistent with its activity as a GABA(A) receptor modulator. GABA(A) receptors could represent a target for androstenol as a pheromone, for which it is well suited because of high volatility and lipophilicity, or as a conventional hormonal neurosteroid. | lld:pubmed |
| pubmed-article:16415088 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415088 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16415088 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415088 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16415088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16415088 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16415088 | pubmed:month | May | lld:pubmed |
| pubmed-article:16415088 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:16415088 | pubmed:author | pubmed-author:ViciniStefano... | lld:pubmed |
| pubmed-article:16415088 | pubmed:author | pubmed-author:RogawskiMicha... | lld:pubmed |
| pubmed-article:16415088 | pubmed:author | pubmed-author:MariniHerbert... | lld:pubmed |
| pubmed-article:16415088 | pubmed:author | pubmed-author:KaminskiRafal... | lld:pubmed |
| pubmed-article:16415088 | pubmed:author | pubmed-author:OrtinskiPavel... | lld:pubmed |
| pubmed-article:16415088 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16415088 | pubmed:volume | 317 | lld:pubmed |
| pubmed-article:16415088 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16415088 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16415088 | pubmed:pagination | 694-703 | lld:pubmed |
| pubmed-article:16415088 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16415088 | pubmed:meshHeading | pubmed-meshheading:16415088... | lld:pubmed |
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| pubmed-article:16415088 | pubmed:meshHeading | pubmed-meshheading:16415088... | lld:pubmed |
| pubmed-article:16415088 | pubmed:meshHeading | pubmed-meshheading:16415088... | lld:pubmed |
| pubmed-article:16415088 | pubmed:meshHeading | pubmed-meshheading:16415088... | lld:pubmed |
| pubmed-article:16415088 | pubmed:meshHeading | pubmed-meshheading:16415088... | lld:pubmed |
| pubmed-article:16415088 | pubmed:meshHeading | pubmed-meshheading:16415088... | lld:pubmed |
| pubmed-article:16415088 | pubmed:meshHeading | pubmed-meshheading:16415088... | lld:pubmed |
| pubmed-article:16415088 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16415088 | pubmed:articleTitle | The pheromone androstenol (5 alpha-androst-16-en-3 alpha-ol) is a neurosteroid positive modulator of GABAA receptors. | lld:pubmed |
| pubmed-article:16415088 | pubmed:affiliation | Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:16415088 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16415088 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:16415088 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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