| pubmed-article:1641126 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0020731 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0010097 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0162512 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0138352 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0916121 | lld:lifeskim |
| pubmed-article:1641126 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1641126 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1641126 | pubmed:dateCreated | 1992-9-3 | lld:pubmed |
| pubmed-article:1641126 | pubmed:abstractText | The effect of a unilateral intrastriatal microinjection of pertussis toxin on the expression of proneurotensin and preproenkephalin A mRNAs in the adult rat neostriatum was investigated using a technique of non-radioactive in situ hybridization. Control sham microinjected animals received an equal volume of vehicle only and were processed in parallel with the pertussis toxin-treated rats. All rats were allowed to recover from the stereotaxic surgery for 22 h before being killed and their brains rapidly removed and processed for in situ hybridization using alkaline phosphatase-labelled oligonucleotide probes. In comparison to sham microinjected rats, a single intrastriatal microinjection of pertussis toxin (1 microgram) resulted in a significant increase in the amount of both proneurotensin and preproenkephalin A mRNAs in the ipsilateral neostriatum. For proneurotensin mRNA, this increase was reflected by a substantial increase in the number of mRNA-containing cells detected. Proneurotensin mRNA-containing cells detected in the nucleus accumbens appeared to be unaffected by the intrastriatal pertussis toxin microinjection. In contrast, the significant increase in preproenkephalin A mRNA, when compared to the contralateral uninjected striatum and the ipsilateral striatum of control sham injected rats, was reflected by an increase in the cellular amount of preproenkephalin A mRNA and not by an increase in the number of mRNA-containing cells detected. These results demonstrate that the expression of both proneurotensin mRNA and preproenkephalin A mRNA in the adult rat striatum are rapidly increased in vivo by an intrastriatal microinjection of pertussis toxin. | lld:pubmed |
| pubmed-article:1641126 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1641126 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1641126 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1641126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1641126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1641126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1641126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1641126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1641126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1641126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1641126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1641126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1641126 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1641126 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:1641126 | pubmed:author | pubmed-author:EmsonP CPC | lld:pubmed |
| pubmed-article:1641126 | pubmed:author | pubmed-author:AugoodS JSJ | lld:pubmed |
| pubmed-article:1641126 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1641126 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:1641126 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1641126 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1641126 | pubmed:pagination | 317-24 | lld:pubmed |
| pubmed-article:1641126 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:meshHeading | pubmed-meshheading:1641126-... | lld:pubmed |
| pubmed-article:1641126 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1641126 | pubmed:articleTitle | Pertussis toxin administration increases the expression of proneurotensin and preproenkephalin A mRNAs in rat striatum. | lld:pubmed |
| pubmed-article:1641126 | pubmed:affiliation | Department of Neuroendocrinology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K. | lld:pubmed |
| pubmed-article:1641126 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1641126 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
