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pubmed-article:16410145pubmed:abstractTextWhether faulty DNA synthesis contributes to neuroblastoma (NB) pathogenesis has received little attention. We have shown that NB DNA replication is orchestrated by a multiprotein DNA replication complex (DNA synthesome) which mediates error-prone DNA synthesis. We sought to define proteomic alterations of the NB DNA synthesome, which lead to lowered replication fidelity.lld:pubmed
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pubmed-article:16410145pubmed:articleTitleStructural analysis of the human neuroblastoma DNA replication complex: insights into faulty proliferation.lld:pubmed
pubmed-article:16410145pubmed:affiliationDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.lld:pubmed
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