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| pubmed-article:164015 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:164015 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:164015 | lifeskim:mentions | umls-concept:C0019652 | lld:lifeskim |
| pubmed-article:164015 | lifeskim:mentions | umls-concept:C2745955 | lld:lifeskim |
| pubmed-article:164015 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:164015 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:164015 | pubmed:dateCreated | 1975-6-11 | lld:pubmed |
| pubmed-article:164015 | pubmed:abstractText | Poly(ADP-ribose) bound to histones has been isolated from rat liver. When [14C]ribose was administered intraperitoneally to rats at a dosage of 300-750 mug (100-250 muCi)/10o g, approximately 1% of the radioactivity was recovered in the acid (5% CLCCCOOH)-INSOLUBLE MATERIAL OF THE LIVER NUCLEI 2 HR AFTER INJECTION. Of the acid-insoluble radioactivity, 4.5-9% was extractable with 0.25 N HCL. Carboxymethyl-cellulose column chromatography of the HCl-extracted material revealed that the radioactivity cochromatographed with histone subfractions f1 and, to a lesser extent, f2 and f3. Part of the protein-bound radioactivity was rendered acid-soluble by treatment with either snake venom phosphodiesterase or neutral NH2OH. From the enzyme digest, 5'-AMP and psiADP-ribose [2'-(5"-phosphoribosyl)-5'-AMP] were recovered, while the NH2OH treatment yielded ADP-ribose monomer and, presumably, oligomer. These observations indicate that ADP-ribose is attached to histones in vivo and is present both as a monomer and a polymer. | lld:pubmed |
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| pubmed-article:164015 | pubmed:language | eng | lld:pubmed |
| pubmed-article:164015 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:164015 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:164015 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:164015 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:164015 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:164015 | pubmed:author | pubmed-author:OmachiAA | lld:pubmed |
| pubmed-article:164015 | pubmed:author | pubmed-author:HayaishiOO | lld:pubmed |
| pubmed-article:164015 | pubmed:author | pubmed-author:UedaKK | lld:pubmed |
| pubmed-article:164015 | pubmed:author | pubmed-author:KawaichiMM | lld:pubmed |
| pubmed-article:164015 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:164015 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:164015 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:164015 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:164015 | pubmed:pagination | 205-9 | lld:pubmed |
| pubmed-article:164015 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:164015 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:164015 | pubmed:articleTitle | Natural occurrence of poly(ADP-ribosyl) histones in rat liver. | lld:pubmed |
| pubmed-article:164015 | pubmed:publicationType | Journal Article | lld:pubmed |
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