| pubmed-article:16396931 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16396931 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16396931 | lifeskim:mentions | umls-concept:C1513095 | lld:lifeskim |
| pubmed-article:16396931 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:16396931 | lifeskim:mentions | umls-concept:C0949653 | lld:lifeskim |
| pubmed-article:16396931 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:16396931 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:16396931 | pubmed:issue | Pt 2 | lld:pubmed |
| pubmed-article:16396931 | pubmed:dateCreated | 2006-3-1 | lld:pubmed |
| pubmed-article:16396931 | pubmed:abstractText | Under chronic hypoxia, tumour cells undergo adaptive changes involving hypoxia-inducible factors (HIFs). Here we report that ion currents mediated by Ca2+-activated K+ (K(Ca)) channels in human melanoma IGR1 cells are increased by chronic hypoxia (3% O2), as well as by hypoxia mimetics. This increase involves the HIF system as confirmed by overexpression of HIF-1alpha or the von Hippel-Lindau tumour suppressor gene. Under normoxic conditions the K(Ca) channels in IGR1 cells showed pharmacological characteristics of intermediate conductance K(Ca) subtype IK channels, whereas the subtype SK2 channels were up-regulated under hypoxia, shown with pharmacological tools and with mRNA analysis. Hypoxia increased cell proliferation, but the K(Ca) channel blockers apamin and charybdotoxin slowed down cell growth, particularly under hypoxic conditions. Similar results were obtained for the cell line IGR39 and for acutely isolated cells from a biopsy of a melanoma metastasis. Thus, up-regulation of K(Ca) channels may be a novel mechanism by which HIFs can contribute to the malignant phenotype of human tumour cells. | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16396931 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16396931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16396931 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16396931 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16396931 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:16396931 | pubmed:author | pubmed-author:HeinemannStef... | lld:pubmed |
| pubmed-article:16396931 | pubmed:author | pubmed-author:SchönherrRola... | lld:pubmed |
| pubmed-article:16396931 | pubmed:author | pubmed-author:KaatzMartinM | lld:pubmed |
| pubmed-article:16396931 | pubmed:author | pubmed-author:KannoHiroshiH | lld:pubmed |
| pubmed-article:16396931 | pubmed:author | pubmed-author:TajimaNobuyos... | lld:pubmed |
| pubmed-article:16396931 | pubmed:author | pubmed-author:SchönherrKris... | lld:pubmed |
| pubmed-article:16396931 | pubmed:author | pubmed-author:NiedlingSusan... | lld:pubmed |
| pubmed-article:16396931 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16396931 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16396931 | pubmed:volume | 571 | lld:pubmed |
| pubmed-article:16396931 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16396931 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16396931 | pubmed:pagination | 349-59 | lld:pubmed |
| pubmed-article:16396931 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
| pubmed-article:16396931 | pubmed:meshHeading | pubmed-meshheading:16396931... | lld:pubmed |
