pubmed-article:16395311 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:16395311 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
pubmed-article:16395311 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
pubmed-article:16395311 | lifeskim:mentions | umls-concept:C1707937 | lld:lifeskim |
pubmed-article:16395311 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
pubmed-article:16395311 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
pubmed-article:16395311 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
pubmed-article:16395311 | pubmed:issue | 7079 | lld:pubmed |
pubmed-article:16395311 | pubmed:dateCreated | 2006-2-23 | lld:pubmed |
pubmed-article:16395311 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16395311 | pubmed:abstractText | Elucidation of the cellular and molecular mechanisms that maintain mammary epithelial tissue integrity is of broad interest and paramount to the design of more effective treatments for breast cancer. Evidence from both in vitro and in vivo experiments suggests that mammary cell differentiation is a hierarchical process originating in an uncommitted stem cell with self-renewal potential. However, analysis of the properties and regulation of mammary stem cells has been limited by a lack of methods for their prospective isolation. Here we report the use of multi-parameter cell sorting and limiting dilution transplant analysis to demonstrate the purification of a rare subset of adult mouse mammary cells that are able individually to regenerate an entire mammary gland within 6 weeks in vivo while simultaneously executing up to ten symmetrical self-renewal divisions. These mammary stem cells are phenotypically distinct from and give rise to mammary epithelial progenitor cells that produce adherent colonies in vitro. The mammary stem cells are also a rapidly cycling population in the normal adult and have molecular features indicative of a basal position in the mammary epithelium. | lld:pubmed |
pubmed-article:16395311 | pubmed:language | eng | lld:pubmed |
pubmed-article:16395311 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16395311 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:16395311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16395311 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:16395311 | pubmed:month | Feb | lld:pubmed |
pubmed-article:16395311 | pubmed:issn | 1476-4687 | lld:pubmed |
pubmed-article:16395311 | pubmed:author | pubmed-author:ChoiDavidD | lld:pubmed |
pubmed-article:16395311 | pubmed:author | pubmed-author:ShackletonMar... | lld:pubmed |
pubmed-article:16395311 | pubmed:author | pubmed-author:EavesConnie... | lld:pubmed |
pubmed-article:16395311 | pubmed:author | pubmed-author:VaillantFranç... | lld:pubmed |
pubmed-article:16395311 | pubmed:author | pubmed-author:StinglJohnJ | lld:pubmed |
pubmed-article:16395311 | pubmed:author | pubmed-author:EirewPeterP | lld:pubmed |
pubmed-article:16395311 | pubmed:author | pubmed-author:RicketsonIanI | lld:pubmed |
pubmed-article:16395311 | pubmed:author | pubmed-author:LiHaiyan IHI | lld:pubmed |
pubmed-article:16395311 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:16395311 | pubmed:day | 23 | lld:pubmed |
pubmed-article:16395311 | pubmed:volume | 439 | lld:pubmed |
pubmed-article:16395311 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:16395311 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:16395311 | pubmed:pagination | 993-7 | lld:pubmed |
pubmed-article:16395311 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:meshHeading | pubmed-meshheading:16395311... | lld:pubmed |
pubmed-article:16395311 | pubmed:year | 2006 | lld:pubmed |
pubmed-article:16395311 | pubmed:articleTitle | Purification and unique properties of mammary epithelial stem cells. | lld:pubmed |
pubmed-article:16395311 | pubmed:affiliation | Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver V5Z 1L3, British Columbia, Canada. | lld:pubmed |
pubmed-article:16395311 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:16395311 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16395311 | lld:pubmed |