| pubmed-article:16394007 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C0024534 | lld:lifeskim |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16394007 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:16394007 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16394007 | pubmed:dateCreated | 2006-1-5 | lld:pubmed |
| pubmed-article:16394007 | pubmed:abstractText | Platelets have recently been shown to accumulate in brain microvessels of patients with cerebral malaria and to modulate the binding of Plasmodium falciparum-infected red cells to human brain endothelium in vitro. In the present study we used a platelet-endothelial cell coculture model to investigate the mechanisms by which platelets modify the function of human brain microvascular endothelial cells (HBEC). Platelets were found to have a proapoptotic effect on TNF-activated HBEC, and this was contact-dependent, as inhibiting platelet binding prevented endothelial cell killing. We also showed that the supernatants of thrombin-activated platelets killed TNF-stimulated HBEC and that TGF-beta1 was the main molecule involved in endothelial cell death, because its inhibition completely abrogated the activated-platelet supernatant effect. Our data illustrate another aspect of the duality of TGF-beta1 in malaria and may provide new insights into the pathogenesis of cerebral malaria. | lld:pubmed |
| pubmed-article:16394007 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16394007 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16394007 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16394007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16394007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16394007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16394007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16394007 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16394007 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16394007 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16394007 | pubmed:author | pubmed-author:Juhan-VagueIr... | lld:pubmed |
| pubmed-article:16394007 | pubmed:author | pubmed-author:de SouzaJ... | lld:pubmed |
| pubmed-article:16394007 | pubmed:author | pubmed-author:GrauGeorges... | lld:pubmed |
| pubmed-article:16394007 | pubmed:author | pubmed-author:WassmerSamuel... | lld:pubmed |
| pubmed-article:16394007 | pubmed:author | pubmed-author:FrèreCorinneC | lld:pubmed |
| pubmed-article:16394007 | pubmed:author | pubmed-author:CandalFrancis... | lld:pubmed |
| pubmed-article:16394007 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16394007 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16394007 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:16394007 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16394007 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16394007 | pubmed:pagination | 1180-4 | lld:pubmed |
| pubmed-article:16394007 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16394007 | pubmed:meshHeading | pubmed-meshheading:16394007... | lld:pubmed |
| pubmed-article:16394007 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16394007 | pubmed:articleTitle | TGF-beta1 released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: a new mechanism for microvascular lesion during cerebral malaria. | lld:pubmed |
| pubmed-article:16394007 | pubmed:affiliation | Centre National de la Recherche Scientifique, Unité Mixte de Recherche (UMR) 6020, Faculty of Medicine, Institut Fédératif de Recherches (IFR) 48, Université de la Méditerranée, Marseille, France. | lld:pubmed |
| pubmed-article:16394007 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16394007 | pubmed:publicationType | In Vitro | lld:pubmed |
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