| pubmed-article:16391832 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16391832 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16391832 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:16391832 | lifeskim:mentions | umls-concept:C0911014 | lld:lifeskim |
| pubmed-article:16391832 | lifeskim:mentions | umls-concept:C0032520 | lld:lifeskim |
| pubmed-article:16391832 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16391832 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:16391832 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:16391832 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16391832 | pubmed:dateCreated | 2006-1-4 | lld:pubmed |
| pubmed-article:16391832 | pubmed:abstractText | Numerous lines of evidence indicate that ghrelin, an endogenous ligand of the growth hormone-secretagogue receptor, is expressed in the human and rat adrenal cortex. In this study, we examined whether ghrelin gene expression undergoes changes in the human adrenal cortex during aging. Semi-quantitative real-time reverse transcription-polymerase chain reaction demonstrated a highly significant negative correlation between ghrelin mRNA and age in adrenal cortex of 27 patients (aged from 33 to 82 years), who underwent unilateral adrenalectomy/nephrectomy for kidney cancer. No significant differences in the level of adrenal ghrelin expression were observed between males and females. Since it has been previously shown that ghrelin exerts a marked growth-stimulating action on cultured adrenocortical cells, we hypothesize that the down-regulation of ghrelin gene transcription in adrenals could be associated with the reported decrease in adrenal DNA synthesis and mitogenic activity during aging. | lld:pubmed |
| pubmed-article:16391832 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16391832 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16391832 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16391832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16391832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16391832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16391832 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16391832 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16391832 | pubmed:issn | 1107-3756 | lld:pubmed |
| pubmed-article:16391832 | pubmed:author | pubmed-author:AlbertinGiova... | lld:pubmed |
| pubmed-article:16391832 | pubmed:author | pubmed-author:NussdorferGas... | lld:pubmed |
| pubmed-article:16391832 | pubmed:author | pubmed-author:AragonaFrance... | lld:pubmed |
| pubmed-article:16391832 | pubmed:author | pubmed-author:CarraroGianni... | lld:pubmed |
| pubmed-article:16391832 | pubmed:author | pubmed-author:SpinazziRaffa... | lld:pubmed |
| pubmed-article:16391832 | pubmed:author | pubmed-author:FornerisMyria... | lld:pubmed |
| pubmed-article:16391832 | pubmed:author | pubmed-author:CasaleValenti... | lld:pubmed |
| pubmed-article:16391832 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16391832 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:16391832 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16391832 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16391832 | pubmed:pagination | 319-21 | lld:pubmed |
| pubmed-article:16391832 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
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| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
| pubmed-article:16391832 | pubmed:meshHeading | pubmed-meshheading:16391832... | lld:pubmed |
| pubmed-article:16391832 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16391832 | pubmed:articleTitle | Age-dependent decrease in the ghrelin gene expression in the human adrenal cortex: a real-time PCR study. | lld:pubmed |
| pubmed-article:16391832 | pubmed:affiliation | Department of Anatomy and Physiology, Section of Anatomy, University of Padua, I-35121 Padua, Italy. | lld:pubmed |
| pubmed-article:16391832 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:51738 | entrezgene:pubmed | pubmed-article:16391832 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16391832 | lld:entrezgene |
