| pubmed-article:16382154 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16382154 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:16382154 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:16382154 | lifeskim:mentions | umls-concept:C1512810 | lld:lifeskim |
| pubmed-article:16382154 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16382154 | pubmed:dateCreated | 2005-12-29 | lld:pubmed |
| pubmed-article:16382154 | pubmed:abstractText | Studies in tissue culture cells have demonstrated a role for the Ras-like GTPase Rap1 in the regulation of integrin-mediated cell-matrix and cadherin-mediated cell-cell contacts. To analyze the function of Rap1 in vivo, we have disrupted the Rap1A gene by homologous recombination. Mice homozygous for the deletion allele are viable and fertile. However, primary hematopoietic cells isolated from spleen or thymus have a diminished adhesive capacity on ICAM and fibronectin substrates. In addition, polarization of T cells from Rap1-/- cells after CD3 stimulation was impaired compared to that of wild-type cells. Despite this, these defects did not result in hematopoietic or cell homing abnormalities. Although it is possible that the relatively mild phenotype is a consequence of functional complementation by the Rap1B gene, our genetic studies confirm a role for Rap1A in the regulation of integrins. | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16382154 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16382154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16382154 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16382154 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16382154 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:16382154 | pubmed:author | pubmed-author:ZwartkruisFri... | lld:pubmed |
| pubmed-article:16382154 | pubmed:author | pubmed-author:ZemojtelTomas... | lld:pubmed |
| pubmed-article:16382154 | pubmed:author | pubmed-author:KolanczykMate... | lld:pubmed |
| pubmed-article:16382154 | pubmed:author | pubmed-author:GrossmannStef... | lld:pubmed |
| pubmed-article:16382154 | pubmed:author | pubmed-author:DuchniewiczMa... | lld:pubmed |
| pubmed-article:16382154 | pubmed:author | pubmed-author:ScheeleJürgen... | lld:pubmed |
| pubmed-article:16382154 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16382154 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16382154 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16382154 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16382154 | pubmed:pagination | 643-53 | lld:pubmed |
| pubmed-article:16382154 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:meshHeading | pubmed-meshheading:16382154... | lld:pubmed |
| pubmed-article:16382154 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16382154 | pubmed:articleTitle | Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion. | lld:pubmed |
| pubmed-article:16382154 | pubmed:affiliation | Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D-14195 Berlin, Germany. | lld:pubmed |
| pubmed-article:16382154 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16382154 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:16382154 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:109905 | entrezgene:pubmed | pubmed-article:16382154 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16382154 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16382154 | lld:pubmed |
