Linked Life Data

16380472

Source:http://linkedlifedata.com/resource/pubmed/id/16380472

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16380472rdf:typepubmed:Citationlld:pubmed
pubmed-article:16380472lifeskim:mentionsumls-concept:C0028754lld:lifeskim
pubmed-article:16380472lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:16380472lifeskim:mentionsumls-concept:C0012155lld:lifeskim
pubmed-article:16380472lifeskim:mentionsumls-concept:C0597357lld:lifeskim
pubmed-article:16380472lifeskim:mentionsumls-concept:C0678226lld:lifeskim
pubmed-article:16380472lifeskim:mentionsumls-concept:C0011155lld:lifeskim
pubmed-article:16380472lifeskim:mentionsumls-concept:C0205173lld:lifeskim
pubmed-article:16380472pubmed:issue1lld:pubmed
pubmed-article:16380472pubmed:dateCreated2005-12-28lld:pubmed
pubmed-article:16380472pubmed:abstractTextNeuropeptide Y receptors are critical regulators of energy homeostasis, but the functional interactions and relative contributions of Y receptors and the environment in this process are unknown. We measured the effects of an ad libitum diet of normal or high-fat food on energy balance in mice with single, double, or triple deficiencies of Y1, Y2, or Y4 receptors. Whereas wild-type mice developed diet-induced obesity, Y2Y4 double knockouts did not. In contrast, Y1 knockout or Y1Y2 or Y1Y4 receptor double knockout mice developed an exacerbated diet-induced obesity syndrome. Remarkably, the antiobesity effect of Y2Y4 deficiency was stronger than the obesogenic effect of Y1 deficiency, since Y1Y2Y4 triple knockouts did not develop obesity on the high-fat diet. Resistance to diet-induced obesity in Y2Y4 knockouts was associated with reduced food intake and improved glucose tolerance in the absence of changes in total physical activity. Fecal concentration of free fatty acids was significantly increased in Y2Y4 knockouts in association with a significantly reduced bile acid pool and marked alterations in intestinal morphology. In addition, hypothalamic proopiomelanocortin expression was decreased in diet-induced obesity (in both wild-type and Y1 receptor knockout mice) but not in obesity-resistant Y2Y4 receptor knockout mice fed a high-fat diet. Therefore, deletion of Y2 and Y4 receptors synergistically protects against diet-induced obesity, at least partially via changes in food intake and hypothalamic proopiomelanocortin expression.lld:pubmed
pubmed-article:16380472pubmed:languageenglld:pubmed
pubmed-article:16380472pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16380472pubmed:citationSubsetAIMlld:pubmed
pubmed-article:16380472pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16380472pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16380472pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16380472pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16380472pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16380472pubmed:statusMEDLINElld:pubmed
pubmed-article:16380472pubmed:monthJanlld:pubmed
pubmed-article:16380472pubmed:issn0012-1797lld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:CooneyGregory...lld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:SainsburyAman...lld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:HerzogHerbert...lld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:CouzensMichel...lld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:SperkGüntherGlld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:BergenHugo...lld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:SingewaldNico...lld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:KarlTimTlld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:LinShuSlld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:BoeyDanaDlld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:EnriquezRonal...lld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:BammingDarjaDlld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:StrothNikolas...lld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:LeeNicola JNJlld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:LindnerDianaDlld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:DuffyLieslLlld:pubmed
pubmed-article:16380472pubmed:authorpubmed-author:SlackKatyKlld:pubmed
pubmed-article:16380472pubmed:issnTypePrintlld:pubmed
pubmed-article:16380472pubmed:volume55lld:pubmed
pubmed-article:16380472pubmed:ownerNLMlld:pubmed
pubmed-article:16380472pubmed:authorsCompleteYlld:pubmed
pubmed-article:16380472pubmed:pagination19-26lld:pubmed
pubmed-article:16380472pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:meshHeadingpubmed-meshheading:16380472...lld:pubmed
pubmed-article:16380472pubmed:year2006lld:pubmed
pubmed-article:16380472pubmed:articleTitleY2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice.lld:pubmed
pubmed-article:16380472pubmed:affiliationNeurobiology Program, The Garvan Institute of Medical Research, St. Vincent's Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia. a.sainsbury-salis@garvan.org.aulld:pubmed
pubmed-article:16380472pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16380472pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:18166entrezgene:pubmedpubmed-article:16380472lld:entrezgene
entrez-gene:18167entrezgene:pubmedpubmed-article:16380472lld:entrezgene
entrez-gene:19065entrezgene:pubmedpubmed-article:16380472lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:16380472lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:16380472lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:16380472lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16380472lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16380472lld:pubmed