| pubmed-article:16374909 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16374909 | lifeskim:mentions | umls-concept:C1510464 | lld:lifeskim |
| pubmed-article:16374909 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:16374909 | lifeskim:mentions | umls-concept:C0242356 | lld:lifeskim |
| pubmed-article:16374909 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:16374909 | lifeskim:mentions | umls-concept:C0012751 | lld:lifeskim |
| pubmed-article:16374909 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16374909 | pubmed:dateCreated | 2005-12-23 | lld:pubmed |
| pubmed-article:16374909 | pubmed:abstractText | The protein structures determined by NMR (Nuclear Magnetic Resonance Spectroscopy) are not as detailed and accurate as those by X-ray crystallography and are often underdetermined due to the inadequate distance data available from NMR experiments. The uses of NMR-determined structures in such important applications as homology modeling and rational drug design have thus been severely limited. Here we show that with the increasing numbers of high quality protein structures being determined, a computational approach to enhancing the accuracy of the NMR-determined structures becomes possible by deriving additional distance constraints from the distributions of the distances in databases of known protein structures. We show through a survey on 462 NMR structures that, in fact, many inter-atomic distances in these structures deviate considerably from their database distributions and based on the refinement results on 10 selected NMR structures that these structures can actually be improved significantly when a selected set of distances are constrained within their high probability ranges in their database distributions. | lld:pubmed |
| pubmed-article:16374909 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16374909 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16374909 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16374909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16374909 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16374909 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16374909 | pubmed:issn | 0219-7200 | lld:pubmed |
| pubmed-article:16374909 | pubmed:author | pubmed-author:CuiFengF | lld:pubmed |
| pubmed-article:16374909 | pubmed:author | pubmed-author:WuZhijunZ | lld:pubmed |
| pubmed-article:16374909 | pubmed:author | pubmed-author:JerniganRober... | lld:pubmed |
| pubmed-article:16374909 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16374909 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:16374909 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16374909 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16374909 | pubmed:pagination | 1315-29 | lld:pubmed |
| pubmed-article:16374909 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16374909 | pubmed:meshHeading | pubmed-meshheading:16374909... | lld:pubmed |
| pubmed-article:16374909 | pubmed:meshHeading | pubmed-meshheading:16374909... | lld:pubmed |
| pubmed-article:16374909 | pubmed:meshHeading | pubmed-meshheading:16374909... | lld:pubmed |
| pubmed-article:16374909 | pubmed:meshHeading | pubmed-meshheading:16374909... | lld:pubmed |
| pubmed-article:16374909 | pubmed:meshHeading | pubmed-meshheading:16374909... | lld:pubmed |
| pubmed-article:16374909 | pubmed:meshHeading | pubmed-meshheading:16374909... | lld:pubmed |
| pubmed-article:16374909 | pubmed:meshHeading | pubmed-meshheading:16374909... | lld:pubmed |
| pubmed-article:16374909 | pubmed:meshHeading | pubmed-meshheading:16374909... | lld:pubmed |
| pubmed-article:16374909 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16374909 | pubmed:articleTitle | Refinement of NMR-determined protein structures with database derived distance constraints. | lld:pubmed |
| pubmed-article:16374909 | pubmed:affiliation | Program on Bioinformatics and Computational Biology, Iowa Sate University, Ames, Iowa 50011, USA. fengcui@iastate.edu | lld:pubmed |
| pubmed-article:16374909 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16374909 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16374909 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16374909 | lld:pubmed |
