| pubmed-article:16368719 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16368719 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16368719 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16368719 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16368719 | lifeskim:mentions | umls-concept:C0206131 | lld:lifeskim |
| pubmed-article:16368719 | lifeskim:mentions | umls-concept:C0034785 | lld:lifeskim |
| pubmed-article:16368719 | lifeskim:mentions | umls-concept:C0682972 | lld:lifeskim |
| pubmed-article:16368719 | lifeskim:mentions | umls-concept:C0015259 | lld:lifeskim |
| pubmed-article:16368719 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:16368719 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:16368719 | lifeskim:mentions | umls-concept:C0599896 | lld:lifeskim |
| pubmed-article:16368719 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16368719 | pubmed:dateCreated | 2006-2-1 | lld:pubmed |
| pubmed-article:16368719 | pubmed:abstractText | The effect of exercise on beta-adrenergic receptor (beta-AR) trafficking was investigated in rat adipocytes. The binding sites of a hydrophilic ligand, [(3)H]CGP12177, increased immediately (0 h) and at 3 h after exercise (3 h) but decreased at 24 h after exercise (24 h). The data of immunoblotting revealed that the alterations in the binding sites mainly paralleled the alterations in the beta2-AR proteins in membrane fractions. The protein expressions of both G-protein-coupled receptor kinase (GRK)-2 and beta-arrestin-2 were reduced, with a decline in beta2-AR ubiquitination at 0 h and 3 h. The protein expressions of beta2-AR, GRK-2, beta-arrestin-2, the beta2-AR/beta-arrestin-2 complex, and beta2-AR ubiquitination returned to their respective control levels at 24 h, whereas the beta2-AR mRNA level was reduced. Administration of either lactacystin or propranolol did not alter GRK-2 and beta2-AR protein expressions after exercise. Thus, the mechanism underlying the increased density of beta2-AR up to at least 3 h may involve alterations in a multistep event involving the coordinate interaction among proteins mediating beta2-AR trafficking, in which both the receptor-agonist interactions and ubiquitin-proteasome pathway have a key role. However, the decreased protein expression of beta2-AR at 24 h might be due to some change occurring at the translational levels. | lld:pubmed |
| pubmed-article:16368719 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16368719 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16368719 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16368719 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16368719 | pubmed:issn | 1530-6860 | lld:pubmed |
| pubmed-article:16368719 | pubmed:author | pubmed-author:KizakiTakakoT | lld:pubmed |
| pubmed-article:16368719 | pubmed:author | pubmed-author:OhnoHidekiH | lld:pubmed |
| pubmed-article:16368719 | pubmed:author | pubmed-author:IzawaTetsuyaT | lld:pubmed |
| pubmed-article:16368719 | pubmed:author | pubmed-author:HitomiYoshiak... | lld:pubmed |
| pubmed-article:16368719 | pubmed:author | pubmed-author:SakuraiTomono... | lld:pubmed |
| pubmed-article:16368719 | pubmed:author | pubmed-author:OgasawaraJune... | lld:pubmed |
| pubmed-article:16368719 | pubmed:author | pubmed-author:RahmanNazibur... | lld:pubmed |
| pubmed-article:16368719 | pubmed:author | pubmed-author:SanpeiMinoriM | lld:pubmed |
| pubmed-article:16368719 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16368719 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:16368719 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16368719 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16368719 | pubmed:pagination | 350-2 | lld:pubmed |
| pubmed-article:16368719 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:16368719 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16368719 | pubmed:articleTitle | Beta-adrenergic receptor trafficking by exercise in rat adipocytes: roles of G-protein-coupled receptor kinase-2, beta-arrestin-2, and the ubiquitin-proteasome pathway. | lld:pubmed |
| pubmed-article:16368719 | pubmed:affiliation | Department of Kinesiology, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo, Japan. | lld:pubmed |
| pubmed-article:16368719 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16368719 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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