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pubmed-article:16360841pubmed:abstractTextTo investigate whether a 77C>G polymorphism in exon A of the CD45 gene causing a variant CD45RA expression pattern is associated with the development of idiopathic dilated cardiomyopathy (DCM), we studied a total of 414 individuals (104 patients and 310 controls). CD45RA expression pattern on lymphocytes was examined by flow cytometric analysis and subsequently the CD45 77C>G polymorphism was genotyped by polymerase chain reaction-allele specific restriction enzyme analysis (PCR-ASRA). We found 5 patients and 8 control individuals displaying the variant CD45RA expression pattern. All identified individuals carried the heterozygous CD45 77C>G polymorphism. The frequency of the 77G allele in the patient group was 2.4%, which was not significantly different from 1.3% found in the control group (p=0.327). In conclusion, the data of this preliminary study could not reveal any association between the CD45 77C>G polymorphism and susceptibility to idiopathic DCM in a German population.lld:pubmed
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pubmed-article:16360841pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:16360841pubmed:year2005lld:pubmed
pubmed-article:16360841pubmed:articleTitleNo association between transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77C>G) and idiopathic dilated cardiomyopathy.lld:pubmed
pubmed-article:16360841pubmed:affiliationInstitute for Transfusion Medicine, University Hospital of Jena, Jena, Germany. Hansjoerg.Thude@med.uni-jena.delld:pubmed
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pubmed-article:16360841pubmed:publicationTypeComparative Studylld:pubmed
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