| pubmed-article:16352737 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16352737 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:16352737 | lifeskim:mentions | umls-concept:C0041327 | lld:lifeskim |
| pubmed-article:16352737 | lifeskim:mentions | umls-concept:C0128897 | lld:lifeskim |
| pubmed-article:16352737 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:16352737 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:16352737 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:16352737 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:16352737 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:16352737 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16352737 | pubmed:dateCreated | 2005-12-20 | lld:pubmed |
| pubmed-article:16352737 | pubmed:abstractText | We examined the distribution of single nucleotide polymorphisms (SNPs) in nitric oxide synthase 2A, monocyte chemoattractant protein-1 (MCP-1), regulated on activation, normal T cell expressed and secreted, and macrophage inflammatory protein-1alpha genes in tuberculosis patients and healthy controls from Mexico. The odds of developing tuberculosis were 2.3- and 5.4-fold higher in carriers of MCP-1 genotypes AG and GG than in homozygous AA. Cases of homozygous GG had the highest plasma levels of MCP-1 and the lowest plasma levels of IL-12p40, and these values were negatively correlated. Furthermore, stimulation of monocytes from healthy carriers of the genotype GG with Mycobacterium tuberculosis antigens yielded higher MCP-1 and lower IL-12p40 concentrations than parallel experiments with monocytes from homozygous AA. Addition of anti-MCP-1 increased IL-12p40 levels in cultures of M. tuberculosis-stimulated monocytes from homozygous GG, and addition of exogenous MCP-1 reduced IL-12p40 production by M. tuberculosis-stimulated monocytes from homozygous AA. Furthermore, we could replicate our results in Korean subjects, in whom the odds of developing tuberculosis were 2.8- and 6.9-fold higher in carriers of MCP-1 genotypes AG and GG than in homozygous AA. Our findings suggest that persons bearing the MCP-1 genotype GG produce high concentrations of MCP-1, which inhibits production of IL-12p40 in response to M. tuberculosis and increases the likelihood that M. tuberculosis infection will progress to active pulmonary tuberculosis. | lld:pubmed |
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| pubmed-article:16352737 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16352737 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16352737 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16352737 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16352737 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:16352737 | pubmed:author | pubmed-author:Ruiz-MoralesJ... | lld:pubmed |
| pubmed-article:16352737 | pubmed:author | pubmed-author:GranadosJulio... | lld:pubmed |
| pubmed-article:16352737 | pubmed:author | pubmed-author:SelmanMoisesM | lld:pubmed |
| pubmed-article:16352737 | pubmed:author | pubmed-author:BarnesPeter... | lld:pubmed |
| pubmed-article:16352737 | pubmed:author | pubmed-author:Flores-Villan... | lld:pubmed |
| pubmed-article:16352737 | pubmed:author | pubmed-author:JoEun-KyeongE... | lld:pubmed |
| pubmed-article:16352737 | pubmed:author | pubmed-author:SongChang-Hwa... | lld:pubmed |
| pubmed-article:16352737 | pubmed:author | pubmed-author:FloresLudmila... | lld:pubmed |
| pubmed-article:16352737 | pubmed:author | pubmed-author:MontañoMartaM | lld:pubmed |
| pubmed-article:16352737 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16352737 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:16352737 | pubmed:volume | 202 | lld:pubmed |
| pubmed-article:16352737 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16352737 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16352737 | pubmed:pagination | 1649-58 | lld:pubmed |
| pubmed-article:16352737 | pubmed:dateRevised | 2011-10-27 | lld:pubmed |
| pubmed-article:16352737 | pubmed:meshHeading | pubmed-meshheading:16352737... | lld:pubmed |
