| pubmed-article:16345024 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16345024 | lifeskim:mentions | umls-concept:C0497327 | lld:lifeskim |
| pubmed-article:16345024 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:16345024 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:16345024 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16345024 | lifeskim:mentions | umls-concept:C1705165 | lld:lifeskim |
| pubmed-article:16345024 | lifeskim:mentions | umls-concept:C0439605 | lld:lifeskim |
| pubmed-article:16345024 | lifeskim:mentions | umls-concept:C1522138 | lld:lifeskim |
| pubmed-article:16345024 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:16345024 | lifeskim:mentions | umls-concept:C0023981 | lld:lifeskim |
| pubmed-article:16345024 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:16345024 | lifeskim:mentions | umls-concept:C2700061 | lld:lifeskim |
| pubmed-article:16345024 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16345024 | pubmed:dateCreated | 2006-12-28 | lld:pubmed |
| pubmed-article:16345024 | pubmed:abstractText | Multi-state models are appealing tools for analysing data about the progression of a disease over time. In this paper, we consider a multi-state Markov chain with two competing absorbing states: dementia and death and three transient non-demented states: cognitively normal, amnestic mild cognitive impairment (amnestic MCI), and non-amnestic mild cognitive impairment (non-amnestic MCI). The likelihood function for the data is derived and estimates for the effects of the covariates on transitions are determined when the process can be viewed as a polytomous logistic regression model with shared random effects. The presence of a shared random effect not only complicates the formulation of the likelihood but also its evaluation and maximization. Three approaches for maximizing the likelihood are compared using a simulation study; the first method is based on the Gauss-quadrature technique, the second method is based on importance sampling ideas, and the third method is based on an expansion by Taylor series. The best approach is illustrated using a longitudinal study on a cohort of cognitively normal subjects, followed annually for conversion to mild cognitive impairment (MCI) and/or dementia, conducted at the Sanders Brown Center on Aging at the University of Kentucky. | lld:pubmed |
| pubmed-article:16345024 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16345024 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16345024 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16345024 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16345024 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16345024 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16345024 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16345024 | pubmed:issn | 0277-6715 | lld:pubmed |
| pubmed-article:16345024 | pubmed:author | pubmed-author:YuLeiL | lld:pubmed |
| pubmed-article:16345024 | pubmed:author | pubmed-author:SalazarJuan... | lld:pubmed |
| pubmed-article:16345024 | pubmed:author | pubmed-author:SchmittFreder... | lld:pubmed |
| pubmed-article:16345024 | pubmed:author | pubmed-author:KryscioRichar... | lld:pubmed |
| pubmed-article:16345024 | pubmed:author | pubmed-author:MendiondoMart... | lld:pubmed |
| pubmed-article:16345024 | pubmed:copyrightInfo | 2006 John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:16345024 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16345024 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:16345024 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16345024 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16345024 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16345024 | pubmed:pagination | 568-80 | lld:pubmed |
| pubmed-article:16345024 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:meshHeading | pubmed-meshheading:16345024... | lld:pubmed |
| pubmed-article:16345024 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:16345024 | pubmed:articleTitle | Shared random effects analysis of multi-state Markov models: application to a longitudinal study of transitions to dementia. | lld:pubmed |
| pubmed-article:16345024 | pubmed:affiliation | Universidad Nacional de Colombia at Medellín, Escuela de Estadística, Medellin, Colombia. | lld:pubmed |
| pubmed-article:16345024 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16345024 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16345024 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16345024 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16345024 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16345024 | lld:pubmed |
