| pubmed-article:16343908 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16343908 | lifeskim:mentions | umls-concept:C0003392 | lld:lifeskim |
| pubmed-article:16343908 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:16343908 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:16343908 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:16343908 | lifeskim:mentions | umls-concept:C0055754 | lld:lifeskim |
| pubmed-article:16343908 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:16343908 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16343908 | pubmed:dateCreated | 2006-3-10 | lld:pubmed |
| pubmed-article:16343908 | pubmed:abstractText | It has been reported that 2-hydroxycinnamaldehyde and 2-benzoyl-oxycinnamaldehyde inhibited the activity of farnesyl protein transferase, angiogenesis, cell-cell adhesion, and tumor growth in vivo model. In order to improve its anti-tumor activity, dimeric cinnamaldehydes have been synthesized based on 2-hydroxycinnamaldehyde. The synthesized compounds strongly inhibited the growth of human colon tumor cells with GI50 values of 0.6-10 microM. Especially, 2-piperazine derivative blocked in vivo growth of human colon tumor xenograft in nude mice at 10 mg/kg. It was found that their anti-tumor effects induce apoptosis and cell cycle arrest at G2/M phase by the compounds. It was confirmed by detection of apoptosis markers such as activated caspase-3 and cleaved PARP, and cell cycle analysis. The dimeric compounds also inhibited Cdc25B phosphatase which is essential for preinitiating G2/M transition and S phase progression. | lld:pubmed |
| pubmed-article:16343908 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16343908 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16343908 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16343908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16343908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16343908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16343908 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16343908 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16343908 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:KimKwang-RokK... | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:SonKwang-HeeK... | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:KwonByoung-Mo... | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:KimHwan-MookH... | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:HanDong ChoDC | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:KangSung... | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:LeeSeung... | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:LeeSu-KyungSK | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:SungNack-DoND | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:CheonHyae-Gye... | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:KimJong-HanJH | lld:pubmed |
| pubmed-article:16343908 | pubmed:author | pubmed-author:ShinDae-SeopD... | lld:pubmed |
| pubmed-article:16343908 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16343908 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16343908 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:16343908 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16343908 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16343908 | pubmed:pagination | 2498-506 | lld:pubmed |
| pubmed-article:16343908 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:meshHeading | pubmed-meshheading:16343908... | lld:pubmed |
| pubmed-article:16343908 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16343908 | pubmed:articleTitle | Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents. | lld:pubmed |
| pubmed-article:16343908 | pubmed:affiliation | Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosung, Taejeon 305-600, Republic of Korea. | lld:pubmed |
| pubmed-article:16343908 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16343908 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
