| pubmed-article:16341147 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16341147 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:16341147 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16341147 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:16341147 | lifeskim:mentions | umls-concept:C0024204 | lld:lifeskim |
| pubmed-article:16341147 | lifeskim:mentions | umls-concept:C0032520 | lld:lifeskim |
| pubmed-article:16341147 | lifeskim:mentions | umls-concept:C0021044 | lld:lifeskim |
| pubmed-article:16341147 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:16341147 | lifeskim:mentions | umls-concept:C0182967 | lld:lifeskim |
| pubmed-article:16341147 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:16341147 | lifeskim:mentions | umls-concept:C0444498 | lld:lifeskim |
| pubmed-article:16341147 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16341147 | pubmed:dateCreated | 2006-1-20 | lld:pubmed |
| pubmed-article:16341147 | pubmed:abstractText | In Thailand, the predominant HIV subtype is E, rather than subtype B as in North America and Europe. Subtype E has the ability to replicate in vitro in Langerhans cells. We hypothesized that this cell type might constitute a reservoir for the HIV virus in infected lymph nodes. We examined lymph nodes from 25 HIV-1 subtype E-infected patients to determine the immunophenotype of HIV-1-infected cells, their numbers and their distribution. The presence of HIV was detected either by in situ reverse transcriptase-polymerase chain reaction or immunoperoxidase. Cell identity was determined by double labelling using alkaline phosphatase-based immunohistochemistry. The majority of HIV-infected cells in the lymph nodes were Langerhans cells (CD1a+S100+) and Langerhans-related dendritic cells (p55+S100+). These cells were located in the paracortical areas of lymph nodes, with a few cells scattered at the edges of germinal centers, but were absent from germinal centers themselves, in contrast to the reported distribution of subtype B virus. In addition, multinucleated giant cells were significantly more common in HIV-infected nodes (64%) compared to controls (4%) (P=0.00002). In conclusion, Langerhans histiocytes and related cells are reservoirs for HIV subtype E in lymph nodes. Disrupting the pathway of infection of Langerhans cells and related cells may be a viable strategy to interfere with transmission of HIV subtype E. | lld:pubmed |
| pubmed-article:16341147 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16341147 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16341147 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16341147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16341147 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16341147 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16341147 | pubmed:issn | 0893-3952 | lld:pubmed |
| pubmed-article:16341147 | pubmed:author | pubmed-author:Khunamornpong... | lld:pubmed |
| pubmed-article:16341147 | pubmed:author | pubmed-author:ThornerPaul... | lld:pubmed |
| pubmed-article:16341147 | pubmed:author | pubmed-author:TaylorClive... | lld:pubmed |
| pubmed-article:16341147 | pubmed:author | pubmed-author:BhoopatLertla... | lld:pubmed |
| pubmed-article:16341147 | pubmed:author | pubmed-author:BhoopatTaninT | lld:pubmed |
| pubmed-article:16341147 | pubmed:author | pubmed-author:RithapornTat... | lld:pubmed |
| pubmed-article:16341147 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16341147 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:16341147 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16341147 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16341147 | pubmed:pagination | 255-63 | lld:pubmed |
| pubmed-article:16341147 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16341147 | pubmed:meshHeading | pubmed-meshheading:16341147... | lld:pubmed |
| pubmed-article:16341147 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16341147 | pubmed:articleTitle | Cell reservoirs in lymph nodes infected with HIV-1 subtype E differ from subtype B: identification by combined in situ polymerase chain reaction and immunohistochemistry. | lld:pubmed |
| pubmed-article:16341147 | pubmed:affiliation | Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. lbhoopat@mail.med.cmu.ac.th | lld:pubmed |
| pubmed-article:16341147 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16341147 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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