Linked Life Data

16340246

Source:http://linkedlifedata.com/resource/pubmed/id/16340246

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pubmed-article:16340246pubmed:abstractTextThe 25-kDa heat shock protein (Hsp25) is associated with various malignancies and is expressed at high levels in biopsies as well as circulating in the serum of breast cancer patients. In this study, we used RNA interference technology to silence the hsp25 gene in 4T1 breast adenocarcinoma cells, known as a poorly immunogenic, highly metastatic cell line. We demonstrate that transfection of 4T1 cells with short interference RNA-Hsp25 dramatically inhibits proliferation as compared with control transfected cells. In addition, we show that 4T1 cells transfected with short interference RNA-Hsp25 abrogates tumor migration potential by a mechanism that is in part due to the repression of matrix metalloproteinase 9 expression and a concomitant upregulation of its antagonist, tissue inhibitor metalloproteinase 1. Taken together, these findings provide a model system for the study of metastatic potential of tumors and are suggestive of an earlier unrecognized role for Hsp25 in tumor migration.lld:pubmed
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pubmed-article:16340246pubmed:copyrightInfoCopyright 2006 S. Karger AG, Basel.lld:pubmed
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pubmed-article:16340246pubmed:articleTitleSilencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell.lld:pubmed
pubmed-article:16340246pubmed:affiliationCenter for Molecular Stress Response, Boston University Medical Center and Boston University School of Medicine, Mass., USA.lld:pubmed
pubmed-article:16340246pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16340246pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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