Linked Life Data

16339173

Source:http://linkedlifedata.com/resource/pubmed/id/16339173

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16339173rdf:typepubmed:Citationlld:pubmed
pubmed-article:16339173lifeskim:mentionsumls-concept:C0044602lld:lifeskim
pubmed-article:16339173lifeskim:mentionsumls-concept:C0887872lld:lifeskim
pubmed-article:16339173lifeskim:mentionsumls-concept:C0282639lld:lifeskim
pubmed-article:16339173lifeskim:mentionsumls-concept:C2936824lld:lifeskim
pubmed-article:16339173lifeskim:mentionsumls-concept:C1704675lld:lifeskim
pubmed-article:16339173lifeskim:mentionsumls-concept:C0033414lld:lifeskim
pubmed-article:16339173lifeskim:mentionsumls-concept:C1710082lld:lifeskim
pubmed-article:16339173lifeskim:mentionsumls-concept:C1879748lld:lifeskim
pubmed-article:16339173lifeskim:mentionsumls-concept:C1706853lld:lifeskim
pubmed-article:16339173pubmed:issuePt 1lld:pubmed
pubmed-article:16339173pubmed:dateCreated2005-12-22lld:pubmed
pubmed-article:16339173pubmed:abstractTextHuman intestinal cell differentiation is mediated by signaling pathways that remain largely undefined. We and others have shown that cell migration and differentiation along the crypt-villus axis is associated with temporal and spatial modulations of the repertoire, as well as with the function of integrins and E-cadherins and their substrates. Cross-talk between integrin and cadherin signaling was previously described and seems to coordinate this differentiation process. Here, we report that engagement of alpha6 and, to a lesser extent, alpha3 integrin subunits after HT-29 cell adhesion on laminin 5 increases the expression of E-cadherin, which then organizes into nascent adherens junctions. We further identify that phosphoinositide 3-kinase (PI 3-kinase) activation plays a key role in this cross-talk. Indeed, integrin-dependent adhesion on laminin 5 stimulates PI 3-kinase activity. Immunofluorescence and immunoprecipitation experiments revealed that activated PI 3-kinase is recruited at cell-cell contacts. Using LY294002, an inhibitor of PI 3-kinase activity, we found that this activation is essential for E-cadherin connection with the cytoskeleton and for biogenesis of adherens junctions. Finally, we demonstrated that PI 3-kinase could signal through Rac1b activation to control adherens junction assembly. Our results provide a mechanistic insight into integrin-cadherin cross-talk and identify a novel role for PI 3-kinase in the establishment of adherens junctions.lld:pubmed
pubmed-article:16339173pubmed:languageenglld:pubmed
pubmed-article:16339173pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:citationSubsetIMlld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16339173pubmed:statusMEDLINElld:pubmed
pubmed-article:16339173pubmed:monthJanlld:pubmed
pubmed-article:16339173pubmed:issn0021-9533lld:pubmed
pubmed-article:16339173pubmed:authorpubmed-author:BlockMarc RMRlld:pubmed
pubmed-article:16339173pubmed:authorpubmed-author:MatosPauloPlld:pubmed
pubmed-article:16339173pubmed:authorpubmed-author:ChartierNicol...lld:pubmed
pubmed-article:16339173pubmed:authorpubmed-author:LainéMichèleMlld:pubmed
pubmed-article:16339173pubmed:authorpubmed-author:GoutStéphanie...lld:pubmed
pubmed-article:16339173pubmed:authorpubmed-author:PawlakGéraldi...lld:pubmed
pubmed-article:16339173pubmed:authorpubmed-author:MarieChristia...lld:pubmed
pubmed-article:16339173pubmed:authorpubmed-author:Jacquier-Sarl...lld:pubmed
pubmed-article:16339173pubmed:issnTypePrintlld:pubmed
pubmed-article:16339173pubmed:day1lld:pubmed
pubmed-article:16339173pubmed:volume119lld:pubmed
pubmed-article:16339173pubmed:ownerNLMlld:pubmed
pubmed-article:16339173pubmed:authorsCompleteYlld:pubmed
pubmed-article:16339173pubmed:pagination31-46lld:pubmed
pubmed-article:16339173pubmed:dateRevised2010-11-18lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:meshHeadingpubmed-meshheading:16339173...lld:pubmed
pubmed-article:16339173pubmed:year2006lld:pubmed
pubmed-article:16339173pubmed:articleTitleLaminin-5-integrin interaction signals through PI 3-kinase and Rac1b to promote assembly of adherens junctions in HT-29 cells.lld:pubmed
pubmed-article:16339173pubmed:affiliationLaboratoire d'Etude de la Différenciation et de l'Adhérence Cellulaires, UMR UJF/CNRS 5538, Institut Albert Bonniot, Faculté de Médecine de Grenoble, Domaine de la Merci, 38706 La Tronche Cedex, France.lld:pubmed
pubmed-article:16339173pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16339173pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:3655entrezgene:pubmedpubmed-article:16339173lld:entrezgene
entrez-gene:3675entrezgene:pubmedpubmed-article:16339173lld:entrezgene
entrez-gene:3911entrezgene:pubmedpubmed-article:16339173lld:entrezgene
entrez-gene:5290entrezgene:pubmedpubmed-article:16339173lld:entrezgene
entrez-gene:5879entrezgene:pubmedpubmed-article:16339173lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:16339173lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:16339173lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:16339173lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:16339173lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:16339173lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16339173lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16339173lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16339173lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16339173lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16339173lld:pubmed