| pubmed-article:16337379 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16337379 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:16337379 | lifeskim:mentions | umls-concept:C0023175 | lld:lifeskim |
| pubmed-article:16337379 | lifeskim:mentions | umls-concept:C0220908 | lld:lifeskim |
| pubmed-article:16337379 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:16337379 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:16337379 | lifeskim:mentions | umls-concept:C1553497 | lld:lifeskim |
| pubmed-article:16337379 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:16337379 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16337379 | pubmed:dateCreated | 2006-1-27 | lld:pubmed |
| pubmed-article:16337379 | pubmed:abstractText | We identified new lead candidates which showed potent dual inhibition against phosphodiesterase-1 and 5 by a ligand-based virtual screening optimized for lead evolution. This virtual screening method, consisting of classification and regression tree analysis using 168 2-center pharmacophore descriptors and 12 macroscopic descriptors, demonstrated a high predictive ability for bioactivity of new chemical compounds. The obtained lead candidates were structurally diverse, although only the structure-activity relationship data of hydroxamic acid derivatives were used to configure the prediction model for the virtual screening. | lld:pubmed |
| pubmed-article:16337379 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16337379 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16337379 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16337379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16337379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16337379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16337379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16337379 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16337379 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16337379 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:16337379 | pubmed:author | pubmed-author:YamazakiKazut... | lld:pubmed |
| pubmed-article:16337379 | pubmed:author | pubmed-author:KanaokaMasaha... | lld:pubmed |
| pubmed-article:16337379 | pubmed:author | pubmed-author:DanAkihitoA | lld:pubmed |
| pubmed-article:16337379 | pubmed:author | pubmed-author:KusunoseNaoto... | lld:pubmed |
| pubmed-article:16337379 | pubmed:author | pubmed-author:FujitaKatsuya... | lld:pubmed |
| pubmed-article:16337379 | pubmed:author | pubmed-author:SatoHideshiH | lld:pubmed |
| pubmed-article:16337379 | pubmed:author | pubmed-author:AsanoShigehir... | lld:pubmed |
| pubmed-article:16337379 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16337379 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16337379 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:16337379 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16337379 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16337379 | pubmed:pagination | 1371-9 | lld:pubmed |
| pubmed-article:16337379 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16337379 | pubmed:meshHeading | pubmed-meshheading:16337379... | lld:pubmed |
| pubmed-article:16337379 | pubmed:meshHeading | pubmed-meshheading:16337379... | lld:pubmed |
| pubmed-article:16337379 | pubmed:meshHeading | pubmed-meshheading:16337379... | lld:pubmed |
| pubmed-article:16337379 | pubmed:meshHeading | pubmed-meshheading:16337379... | lld:pubmed |
| pubmed-article:16337379 | pubmed:meshHeading | pubmed-meshheading:16337379... | lld:pubmed |
| pubmed-article:16337379 | pubmed:meshHeading | pubmed-meshheading:16337379... | lld:pubmed |
| pubmed-article:16337379 | pubmed:meshHeading | pubmed-meshheading:16337379... | lld:pubmed |
| pubmed-article:16337379 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16337379 | pubmed:articleTitle | Identification of phosphodiesterase-1 and 5 dual inhibitors by a ligand-based virtual screening optimized for lead evolution. | lld:pubmed |
| pubmed-article:16337379 | pubmed:affiliation | Sumitomo Pharmaceuticals Co., Ltd, 1-98, Kasugade Naka 3-Chome, Konohana-ku, Osaka 554-0022, Japan. kazuto-yamazaki@ds-pharma.co.jp | lld:pubmed |
| pubmed-article:16337379 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:16337379 | lld:chembl |
