| pubmed-article:16333246 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16333246 | lifeskim:mentions | umls-concept:C0231335 | lld:lifeskim |
| pubmed-article:16333246 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
| pubmed-article:16333246 | lifeskim:mentions | umls-concept:C0010711 | lld:lifeskim |
| pubmed-article:16333246 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:16333246 | lifeskim:mentions | umls-concept:C1130454 | lld:lifeskim |
| pubmed-article:16333246 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:16333246 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:16333246 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:16333246 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16333246 | pubmed:dateCreated | 2005-12-7 | lld:pubmed |
| pubmed-article:16333246 | pubmed:abstractText | Cytarabine (ara-C) is the most effective agent for the treatment of acute myeloid leukaemia (AML). Aberrant expression of enzymes involved in the transport/metabolism of ara-C could explain drug resistance. We determined mRNA expression of these factors using quantitative-real-time-PCR in leukemic blasts from children diagnosed with de novo AML. Expression of the inactivating enzyme pyrimidine nucleotidase-I (PN-I) was 1.8-fold lower in FAB-M5 as compared to FAB-M1/2 (P=0.007). In vitro sensitivity to deoxynucleoside analogues was determined using the MTT-assay. Human equilibrative nucleoside transporter-1 (hENT1) mRNA expression and ara-C sensitivity were significantly correlated (rp=-0.46; P=0.001), with three-fold lower hENT1 mRNA levels in resistant patients (P=0.003). hENT1 mRNA expression also seemed to correlate inversely with the LC50 values of cladribine (rp=-0.30; P=0.04), decitabine (rp=-0.29; P=0.04) and gemcitabine (rp=-0.33; P=0.02). Deoxycytidine kinase (dCK) and cytidine deaminase (CDA) mRNA expression seemed to correlate with in vitro sensitivity to gemcitabine (rp=-0.31; P=0.03) and decitabine (rp=0.33; P=0.03), respectively. The dCK/PN-I ratio correlated inversely with LC50 values for gemcitabine (rp=-0.45, P=0.001) and the dCK/CDA ratio seemed to correlate with LC50 values for decitabine (rp=-0.29; 0.04). In conclusion, decreased expression of hENT1, which transports ara-C across the cell membrane, appears to be a major factor in ara-C resistance in childhood AML. | lld:pubmed |
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| pubmed-article:16333246 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16333246 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16333246 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16333246 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16333246 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16333246 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:PetersG JGJ | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:van WeringE... | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:KuikD JDJ | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:PietersRR | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:ZwaanC MCM | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:CreutzigUU | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:CloosJJ | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:BroekhuizenRR | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:HubeekII | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:KaspersG J... | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:MeijerinkJ... | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:GibsonB E SBE | lld:pubmed |
| pubmed-article:16333246 | pubmed:author | pubmed-author:StamR WRW | lld:pubmed |
| pubmed-article:16333246 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16333246 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:16333246 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:16333246 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16333246 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16333246 | pubmed:pagination | 1388-94 | lld:pubmed |
| pubmed-article:16333246 | pubmed:dateRevised | 2010-9-20 | lld:pubmed |
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