| pubmed-article:16333089 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C0019169 | lld:lifeskim |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C0443803 | lld:lifeskim |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C2826293 | lld:lifeskim |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C0039260 | lld:lifeskim |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16333089 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16333089 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16333089 | pubmed:dateCreated | 2005-12-7 | lld:pubmed |
| pubmed-article:16333089 | pubmed:abstractText | To assess the prevalence and clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations in Taiwan, a cohort of 200 Taiwanese chronic hepatitis B patients was analyzed. The HBV genotypes and sequences of the precore and the core promoter regions were determined in 66 asymptomatic carriers and 134 patients who had liver biopsy-verified chronic hepatitis and liver cirrhosis. The HBV e-antigen (HBeAg)-negative patients had a higher frequency of mutations at core promoter nucleotides 1753 and 1773 and precore nucleotides 1846, 1896, and 1899 than HBeAg-positive patients. Among the 200 patients, the frequencies of genotype C, T1762 and A1764, C1753, T1766 and A1768, and A1896 mutations increased and the frequencies of T or G1752, T1773, G1799, and C1858 mutations decreased with advancing liver diseases. These factors were different between those with HBeAg-positive status and those with HBeAg-negative status. Based on multiple logistic regression analysis, the risk factors of liver cirrhosis for 200 patients were the presence of T1762 and A1764 mutations (odds ratio [OR] = 11.11; 95% confidence interval [CI] = 3.91 to 31.25; P < 0.001), age > or =35 years (OR = 3.42; 95% CI = 1.33 to 8.77; P = 0.011), and genotype C (OR = 2.87; 95% CI = 1.21 to 6.81; P = 0.017). Further categorical analysis found that 62.1% of patients with genotype C, T1762 and A1764 mutations and age > or =35 years had liver cirrhosis. None of the 55 patients infected with the genotype B, A1762 and G1764 wild type and age <35 years showed liver cirrhosis. In conclusion, our data suggest that pathogenic differences between HBeAg-positive and -negative patients may exist. In Taiwan, HBV genotype C and the T1762 and A1764 mutations may play a role in HBV-related liver cirrhosis, and these could serve as molecular markers for prediction of the clinical outcomes of chronic HBV patients. | lld:pubmed |
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| pubmed-article:16333089 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16333089 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16333089 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16333089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16333089 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16333089 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16333089 | pubmed:issn | 0095-1137 | lld:pubmed |
| pubmed-article:16333089 | pubmed:author | pubmed-author:LeeChuan-MoCM | lld:pubmed |
| pubmed-article:16333089 | pubmed:author | pubmed-author:LuSheng-NanSN | lld:pubmed |
| pubmed-article:16333089 | pubmed:author | pubmed-author:EngHock-LiewH... | lld:pubmed |
| pubmed-article:16333089 | pubmed:author | pubmed-author:ChenChien-Hun... | lld:pubmed |
| pubmed-article:16333089 | pubmed:author | pubmed-author:ChangchienChi... | lld:pubmed |
| pubmed-article:16333089 | pubmed:author | pubmed-author:WangJing-Houn... | lld:pubmed |
| pubmed-article:16333089 | pubmed:author | pubmed-author:HungChao-Hung... | lld:pubmed |
| pubmed-article:16333089 | pubmed:author | pubmed-author:HuTsung-HuiTH | lld:pubmed |
| pubmed-article:16333089 | pubmed:author | pubmed-author:HuangChao-Min... | lld:pubmed |
| pubmed-article:16333089 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16333089 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:16333089 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16333089 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16333089 | pubmed:pagination | 6000-6 | lld:pubmed |
| pubmed-article:16333089 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16333089 | pubmed:meshHeading | pubmed-meshheading:16333089... | lld:pubmed |
| pubmed-article:16333089 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16333089 | pubmed:articleTitle | Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan. | lld:pubmed |
| pubmed-article:16333089 | pubmed:affiliation | Division of Hepatogastroenterology, Department of Internal Medicine, Kaoshiung Chang Gung Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan. | lld:pubmed |
