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pubmed-article:16327900pubmed:abstractTextStructure-activity relationship studies on CXCR4 antagonists, which were previously found by using cyclic pentapeptide libraries, were performed to optimize side-chain functional groups, involving conformationally constrained analogues. In addition, a new lead of cyclic pentapeptides with the introduction of a novel pharmacophore was developed.lld:pubmed
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pubmed-article:16327900pubmed:articleTitleStructure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds.lld:pubmed
pubmed-article:16327900pubmed:affiliationInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan. tamamura.mr@tmd.ac.jplld:pubmed
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