| pubmed-article:16324710 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16324710 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:16324710 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:16324710 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:16324710 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16324710 | pubmed:dateCreated | 2006-1-2 | lld:pubmed |
| pubmed-article:16324710 | pubmed:abstractText | The aim of this study was to investigate the effects of aging on the profile of myocardial substrate utilization and cardiac function using a physiological profile of substrates. Hearts from 6-, 15- and 24-month male Wistar rats were perfused in the isovolumic Langendorff mode, with physiological concentrations of 13C labeled palmitate, and either 13C labeled lactate or 13C glucose. 13C-NMR glutamate isotopomer analysis was performed to determine the contribution of the different substrates to oxidative metabolism. Palmitate oxidation was significantly increased and lactate oxidation depressed in the 24-month old, senescent hearts compared to the mature 6-month hearts. This metabolic remodeling was paralleled with a marked decline in cardiac function and efficiency. These results highlight that adaptations in substrate utilization occur during senescence and may contribute to the age-related increase in the incidence of heart failure. | lld:pubmed |
| pubmed-article:16324710 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16324710 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324710 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16324710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324710 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16324710 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16324710 | pubmed:issn | 0022-2828 | lld:pubmed |
| pubmed-article:16324710 | pubmed:author | pubmed-author:ClelandJohn... | lld:pubmed |
| pubmed-article:16324710 | pubmed:author | pubmed-author:SeymourAnne-M... | lld:pubmed |
| pubmed-article:16324710 | pubmed:author | pubmed-author:SampleJessica... | lld:pubmed |
| pubmed-article:16324710 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16324710 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:16324710 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16324710 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16324710 | pubmed:pagination | 56-63 | lld:pubmed |
| pubmed-article:16324710 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16324710 | pubmed:meshHeading | pubmed-meshheading:16324710... | lld:pubmed |
| pubmed-article:16324710 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16324710 | pubmed:articleTitle | Metabolic remodeling in the aging heart. | lld:pubmed |
| pubmed-article:16324710 | pubmed:affiliation | Department of Biological Sciences, The University of Hull, Cottingham Road, Kingston-upon-Hull HU6 7RX, UK. | lld:pubmed |
| pubmed-article:16324710 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16324710 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:16324710 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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