| pubmed-article:16319203 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16319203 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16319203 | lifeskim:mentions | umls-concept:C0599332 | lld:lifeskim |
| pubmed-article:16319203 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:16319203 | lifeskim:mentions | umls-concept:C0596019 | lld:lifeskim |
| pubmed-article:16319203 | lifeskim:mentions | umls-concept:C1420091 | lld:lifeskim |
| pubmed-article:16319203 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16319203 | pubmed:dateCreated | 2006-2-22 | lld:pubmed |
| pubmed-article:16319203 | pubmed:abstractText | When stimulated with odorants, olfactory receptor neurons (ORNs) produce a depolarizing receptor current. In isolated ORNs, much of this current is caused by an efflux of Cl-. This implies that the neurons have one or more mechanisms for accumulating cytoplasmic Cl- at rest. Whether odors activate an efflux of Cl- in intact olfactory epithelium, where the ionic environment is poorly characterized, has not been previously determined. In mouse olfactory epithelium, we found that >80% of the summated electrical response to odors is blocked by niflumic acid or flufenamic acid, each of which inhibits Ca2+-activated Cl- channels in ORNs. This indicates that ORNs accumulate Cl- in situ. Recent evidence has shown that NKCC1, a Na+-K+-2Cl- cotransporter, contributes to Cl- accumulation in mammalian ORNs. However, we find that the epithelial response to odors is only reduced by 39% in mice carrying a null mutation in Nkcc1. As in the wild-type, most of the response is blocked by niflumic acid or flufenamic acid, indicating that the underlying current is carried by Cl-. We conclude that ORNs effectively accumulate Cl- in situ even in the absence of NKCC1. The Cl- -transport mechanism underlying this accumulation has not yet been identified. | lld:pubmed |
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| pubmed-article:16319203 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16319203 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16319203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16319203 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16319203 | pubmed:issn | 0022-3077 | lld:pubmed |
| pubmed-article:16319203 | pubmed:author | pubmed-author:KleeneSteven... | lld:pubmed |
| pubmed-article:16319203 | pubmed:author | pubmed-author:GestelandRobe... | lld:pubmed |
| pubmed-article:16319203 | pubmed:author | pubmed-author:NickellWillia... | lld:pubmed |
| pubmed-article:16319203 | pubmed:author | pubmed-author:KleeneNancy... | lld:pubmed |
| pubmed-article:16319203 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16319203 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:16319203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16319203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16319203 | pubmed:pagination | 2003-6 | lld:pubmed |
| pubmed-article:16319203 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16319203 | pubmed:meshHeading | pubmed-meshheading:16319203... | lld:pubmed |
| pubmed-article:16319203 | pubmed:meshHeading | pubmed-meshheading:16319203... | lld:pubmed |
| pubmed-article:16319203 | pubmed:meshHeading | pubmed-meshheading:16319203... | lld:pubmed |
| pubmed-article:16319203 | pubmed:meshHeading | pubmed-meshheading:16319203... | lld:pubmed |
| pubmed-article:16319203 | pubmed:meshHeading | pubmed-meshheading:16319203... | lld:pubmed |
| pubmed-article:16319203 | pubmed:meshHeading | pubmed-meshheading:16319203... | lld:pubmed |
| pubmed-article:16319203 | pubmed:meshHeading | pubmed-meshheading:16319203... | lld:pubmed |
| pubmed-article:16319203 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16319203 | pubmed:articleTitle | Neuronal chloride accumulation in olfactory epithelium of mice lacking NKCC1. | lld:pubmed |
| pubmed-article:16319203 | pubmed:affiliation | Dept. of Cell Biology, Neurobiology, and Anatomy, Univ. of Cincinnati, PO Box 670667, Cincinnati, OH 45267-0667, USA. | lld:pubmed |
| pubmed-article:16319203 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16319203 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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