| pubmed-article:16317097 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16317097 | lifeskim:mentions | umls-concept:C0079744 | lld:lifeskim |
| pubmed-article:16317097 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:16317097 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:16317097 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:16317097 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:16317097 | lifeskim:mentions | umls-concept:C2931151 | lld:lifeskim |
| pubmed-article:16317097 | lifeskim:mentions | umls-concept:C1707513 | lld:lifeskim |
| pubmed-article:16317097 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16317097 | pubmed:dateCreated | 2006-3-6 | lld:pubmed |
| pubmed-article:16317097 | pubmed:abstractText | To identify, in high-resolution regions of DNA, the copy number changes associated with outcome in patients with diffuse large B-cell lymphoma (DLBCL), a disease with an approximately 50% mortality rate, we performed array comparative genomic hybridization (array-CGH) on specimens from 64 patients with newly diagnosed DLBCL treated with anthracycline-based chemotherapy. For the entire cohort, 55 commonly gained/lost regions, ranging in size from less than 1 Mbp to entire chromosomes, were identified using 1- to 2-Mbp and 2- to 4-Mbp resolution BAC arrays. Copy number changes of 9 minimal regions significantly correlated with overall survival, of which 6 were 10 Mbp or smaller. On multivariate analysis, loss of chromosomes 2 (2.4-4.1 Mbp) and 16 (33.8-35.6 Mbp) were found to be prognostic indicators of poor survival, independent of clinical features routinely used to predict outcome. Loss of chromosome 1 (78.2-79.1 Mbp) was predictive of good outcome. For a subset of 55 specimens classified according to cell-of-origin expression signature subtype, gain of chromosome 12 (45.4-53.8 Mbp) was found to be significantly associated with the germinal center B-cell-like DLBCL subtype. Overall, array-CGH identified relatively small genomic regions associated with outcome, which, along with follow-up expression studies, may reveal target genes important in DLBCL clinical behavior. | lld:pubmed |
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| pubmed-article:16317097 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16317097 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16317097 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16317097 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16317097 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16317097 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:16317097 | pubmed:author | pubmed-author:HouldsworthJa... | lld:pubmed |
| pubmed-article:16317097 | pubmed:author | pubmed-author:ChagantiR S... | lld:pubmed |
| pubmed-article:16317097 | pubmed:author | pubmed-author:Teruya-Feldst... | lld:pubmed |
| pubmed-article:16317097 | pubmed:author | pubmed-author:OlshenAdam... | lld:pubmed |
| pubmed-article:16317097 | pubmed:author | pubmed-author:NanjangudGour... | lld:pubmed |
| pubmed-article:16317097 | pubmed:author | pubmed-author:ZelenetzAndre... | lld:pubmed |
| pubmed-article:16317097 | pubmed:author | pubmed-author:ChagantiSeeta... | lld:pubmed |
| pubmed-article:16317097 | pubmed:author | pubmed-author:ChenWeiyiW | lld:pubmed |
| pubmed-article:16317097 | pubmed:author | pubmed-author:VenkatramanEn... | lld:pubmed |
| pubmed-article:16317097 | pubmed:author | pubmed-author:HalaasJeffrey... | lld:pubmed |
| pubmed-article:16317097 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16317097 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16317097 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:16317097 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16317097 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16317097 | pubmed:pagination | 2477-85 | lld:pubmed |
| pubmed-article:16317097 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16317097 | pubmed:meshHeading | pubmed-meshheading:16317097... | lld:pubmed |
| pubmed-article:16317097 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16317097 | pubmed:articleTitle | Array comparative genomic hybridization reveals genomic copy number changes associated with outcome in diffuse large B-cell lymphomas. | lld:pubmed |
| pubmed-article:16317097 | pubmed:affiliation | Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. | lld:pubmed |
| pubmed-article:16317097 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16317097 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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