| pubmed-article:16316644 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16316644 | lifeskim:mentions | umls-concept:C0220806 | lld:lifeskim |
| pubmed-article:16316644 | lifeskim:mentions | umls-concept:C1551338 | lld:lifeskim |
| pubmed-article:16316644 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:16316644 | lifeskim:mentions | umls-concept:C0279023 | lld:lifeskim |
| pubmed-article:16316644 | lifeskim:mentions | umls-concept:C1256369 | lld:lifeskim |
| pubmed-article:16316644 | lifeskim:mentions | umls-concept:C2350958 | lld:lifeskim |
| pubmed-article:16316644 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:16316644 | pubmed:dateCreated | 2005-12-12 | lld:pubmed |
| pubmed-article:16316644 | pubmed:abstractText | The insulinotropic activity of KCP256 [(R)-8-benzyl-2-cyclopentyl-7, 8-dihydro-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one hydrochloride] was examined using MIN6 cells (a pancreatic beta-cell line) and pancreatic islets isolated from rats. Unlike sulfonylurea anti-diabetic drugs, KCP256 dose-dependently (0.1-10 microM) enhanced insulin secretion from MIN6 cells and its insulinotropic effect was exerted only at high concentrations of glucose (8.3-22 mM) but not at low concentrations of glucose (3.3-5.5 mM). Furthermore, the action mechanism of KCP256 was different because, unlike sulfonylurea drugs, KCP256 did not displace the binding of [3H]glibenclamide, and did not inhibit the 86Rb+ efflux nor K(ATP) channel activity. In isolated islets, KCP256 also enhanced insulin secretion in a dose- and a glucose-concentration-dependent manner. Plasma levels of insulin after glucose challenge in KCP256-administrated rats were higher than those in vehicle-administrated animals, indicating that KCP256 can enhance insulin secretion in vivo. Since the insulinotropic activity of KCP256 only occurs at high concentrations of glucose, this novel drug may exhibit a decreased risk of drug-induced hypoglycemia compared with sulfonylurea drugs when treating patients with diabetes. | lld:pubmed |
| pubmed-article:16316644 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16316644 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16316644 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16316644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16316644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16316644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16316644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16316644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16316644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16316644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16316644 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16316644 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16316644 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:16316644 | pubmed:author | pubmed-author:KusakaHideaki... | lld:pubmed |
| pubmed-article:16316644 | pubmed:author | pubmed-author:YanoHiroshiH | lld:pubmed |
| pubmed-article:16316644 | pubmed:author | pubmed-author:NakanishiSato... | lld:pubmed |
| pubmed-article:16316644 | pubmed:author | pubmed-author:NomotoYujiY | lld:pubmed |
| pubmed-article:16316644 | pubmed:author | pubmed-author:MoriKiyotoshi... | lld:pubmed |
| pubmed-article:16316644 | pubmed:author | pubmed-author:TakasakiKotar... | lld:pubmed |
| pubmed-article:16316644 | pubmed:author | pubmed-author:UenoKimihisaK | lld:pubmed |
| pubmed-article:16316644 | pubmed:author | pubmed-author:HigoKatsuyaK | lld:pubmed |
| pubmed-article:16316644 | pubmed:author | pubmed-author:KatohYoshimit... | lld:pubmed |
| pubmed-article:16316644 | pubmed:author | pubmed-author:IchimuraMichi... | lld:pubmed |
| pubmed-article:16316644 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16316644 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:16316644 | pubmed:volume | 528 | lld:pubmed |
| pubmed-article:16316644 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16316644 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16316644 | pubmed:pagination | 176-82 | lld:pubmed |
| pubmed-article:16316644 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:16316644 | pubmed:meshHeading | pubmed-meshheading:16316644... | lld:pubmed |
| pubmed-article:16316644 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16316644 | pubmed:articleTitle | Glucose concentration-dependent potentiation of insulin secretion by a new chemical entity, KCP256. | lld:pubmed |
| pubmed-article:16316644 | pubmed:affiliation | Drug Discovery Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Shizuoka, Japan. kiyotoshi.mori@kyowa.co.jp | lld:pubmed |
| pubmed-article:16316644 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16316644 | pubmed:publicationType | In Vitro | lld:pubmed |
