| pubmed-article:16302289 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16302289 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16302289 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:16302289 | lifeskim:mentions | umls-concept:C0022660 | lld:lifeskim |
| pubmed-article:16302289 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16302289 | lifeskim:mentions | umls-concept:C1433601 | lld:lifeskim |
| pubmed-article:16302289 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16302289 | pubmed:dateCreated | 2005-12-27 | lld:pubmed |
| pubmed-article:16302289 | pubmed:abstractText | The pharmacokinetic parameters of DA-7867 were compared after intravenous and oral administration at a dose of 10 mg/kg to control rats and rats with acute renal failure induced by uranyl nitrate (rats with U-ARF). After intravenous administration in rats with U-ARF, the time-averaged total body clearance (Cl) was significantly faster (2.45 versus 0.932 ml/min/kg) than controls due to significantly faster nonrenal clearance (2.25 versus 0.855 ml/min/kg) in rats with U-ARF. The faster nonrenal clearance could be due to significantly greater gastrointestinal (including biliary) excretion; the amount of unchanged DA-7867 recovered from the entire gastrointestinal tract at 24 h was significantly greater (30.3% versus 9.38% of intravenous dose) in rats with U-ARF. In rats with U-ARF, the Vss was significantly larger (1420 ml/kg compared with 580 ml/kg), but this was not due to a difference in plasma protein binding; the values were comparable between the two groups of rats. After oral administration to rats with U-ARF, the total area under the plasma concentration-time from time zero to time infinity (AUC) of DA-7867 was significantly smaller than the controls (2560 microg min/ml versus 7440 microg min/ml), and this was not due mainly to a decrease in absorption from the gastrointestinal tract in rats with U-ARF. | lld:pubmed |
| pubmed-article:16302289 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16302289 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16302289 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16302289 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16302289 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16302289 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16302289 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16302289 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16302289 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16302289 | pubmed:issn | 0142-2782 | lld:pubmed |
| pubmed-article:16302289 | pubmed:author | pubmed-author:KimWon BWB | lld:pubmed |
| pubmed-article:16302289 | pubmed:author | pubmed-author:LeeInchulI | lld:pubmed |
| pubmed-article:16302289 | pubmed:author | pubmed-author:LeeMyung GMG | lld:pubmed |
| pubmed-article:16302289 | pubmed:author | pubmed-author:KwonJong WJW | lld:pubmed |
| pubmed-article:16302289 | pubmed:author | pubmed-author:BaeSoo KSK | lld:pubmed |
| pubmed-article:16302289 | pubmed:copyrightInfo | Copyright (c) 2005 John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:16302289 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16302289 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:16302289 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16302289 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16302289 | pubmed:pagination | 29-37 | lld:pubmed |
| pubmed-article:16302289 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:16302289 | pubmed:meshHeading | pubmed-meshheading:16302289... | lld:pubmed |
| pubmed-article:16302289 | pubmed:meshHeading | pubmed-meshheading:16302289... | lld:pubmed |
| pubmed-article:16302289 | pubmed:meshHeading | pubmed-meshheading:16302289... | lld:pubmed |
| pubmed-article:16302289 | pubmed:meshHeading | pubmed-meshheading:16302289... | lld:pubmed |
| pubmed-article:16302289 | pubmed:meshHeading | pubmed-meshheading:16302289... | lld:pubmed |
| pubmed-article:16302289 | pubmed:meshHeading | pubmed-meshheading:16302289... | lld:pubmed |
| pubmed-article:16302289 | pubmed:meshHeading | pubmed-meshheading:16302289... | lld:pubmed |
| pubmed-article:16302289 | pubmed:meshHeading | pubmed-meshheading:16302289... | lld:pubmed |
| pubmed-article:16302289 | pubmed:meshHeading | pubmed-meshheading:16302289... | lld:pubmed |
| pubmed-article:16302289 | pubmed:meshHeading | pubmed-meshheading:16302289... | lld:pubmed |
| pubmed-article:16302289 | pubmed:meshHeading | pubmed-meshheading:16302289... | lld:pubmed |
| pubmed-article:16302289 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16302289 | pubmed:articleTitle | Effects of acute renal failure on the pharmacokinetics of DA-7867, a new oxazolidinone, in rats. | lld:pubmed |
| pubmed-article:16302289 | pubmed:affiliation | College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea. | lld:pubmed |
| pubmed-article:16302289 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16302289 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16302289 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
