| pubmed-article:16297973 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16297973 | lifeskim:mentions | umls-concept:C0442504 | lld:lifeskim |
| pubmed-article:16297973 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16297973 | lifeskim:mentions | umls-concept:C0002333 | lld:lifeskim |
| pubmed-article:16297973 | lifeskim:mentions | umls-concept:C0558295 | lld:lifeskim |
| pubmed-article:16297973 | lifeskim:mentions | umls-concept:C0205146 | lld:lifeskim |
| pubmed-article:16297973 | lifeskim:mentions | umls-concept:C1521801 | lld:lifeskim |
| pubmed-article:16297973 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16297973 | pubmed:dateCreated | 2005-12-26 | lld:pubmed |
| pubmed-article:16297973 | pubmed:abstractText | The present experiment was designed to replicate and extend previous results of an opiate+benzodiazepine interaction in which peripherally administered alprazolam was observed to modulate behavior resulting from intravenous injections of heroin. As a first step in determining the role of central sites in this drug interaction, changes in drug reward (measured by conditioned place preference; CPP) were assessed in rats given systemic administration of alprazolam coupled with intracranially infused heroin (into the ventral tegmental area; VTA). Sprague-Dawley rats were implanted with guide cannula targeting the VTA, after which a heroin-induced CPP dose-response curve was determined (2.5-40 ng administered bilaterally in 0.5 microl/side). In other animals, intra-VTA heroin-induced place preferences were challenged with systemically applied alprazolam (0.125 mg/kg i.p.). The data confirm that rats dose-dependently develop reliable place preferences for a distinct environment paired with bilateral VTA-infusions of heroin. Additionally, when a non-rewarding dose of alprazolam was combined with a non-rewarding bilateral intra-VTA heroin dose (5 ng), a significant CPP was produced. These data extend earlier results by demonstrating that a systemically applied benzodiazepine can enhance the rewarding effects produced by central opiate administration. The results suggest that the VTA might be a site where this opiate+benzodiazepine interaction occurs. | lld:pubmed |
| pubmed-article:16297973 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16297973 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16297973 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16297973 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16297973 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16297973 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16297973 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16297973 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16297973 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16297973 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16297973 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16297973 | pubmed:issn | 0091-3057 | lld:pubmed |
| pubmed-article:16297973 | pubmed:author | pubmed-author:EttenbergAaro... | lld:pubmed |
| pubmed-article:16297973 | pubmed:author | pubmed-author:WalkerBrendan... | lld:pubmed |
| pubmed-article:16297973 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16297973 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:16297973 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16297973 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16297973 | pubmed:pagination | 470-7 | lld:pubmed |
| pubmed-article:16297973 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
| pubmed-article:16297973 | pubmed:meshHeading | pubmed-meshheading:16297973... | lld:pubmed |
| pubmed-article:16297973 | pubmed:meshHeading | pubmed-meshheading:16297973... | lld:pubmed |
| pubmed-article:16297973 | pubmed:meshHeading | pubmed-meshheading:16297973... | lld:pubmed |
| pubmed-article:16297973 | pubmed:meshHeading | pubmed-meshheading:16297973... | lld:pubmed |
| pubmed-article:16297973 | pubmed:meshHeading | pubmed-meshheading:16297973... | lld:pubmed |
| pubmed-article:16297973 | pubmed:meshHeading | pubmed-meshheading:16297973... | lld:pubmed |
| pubmed-article:16297973 | pubmed:meshHeading | pubmed-meshheading:16297973... | lld:pubmed |
| pubmed-article:16297973 | pubmed:meshHeading | pubmed-meshheading:16297973... | lld:pubmed |
| pubmed-article:16297973 | pubmed:meshHeading | pubmed-meshheading:16297973... | lld:pubmed |
| pubmed-article:16297973 | pubmed:meshHeading | pubmed-meshheading:16297973... | lld:pubmed |
| pubmed-article:16297973 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16297973 | pubmed:articleTitle | Intra-ventral tegmental area heroin-induced place preferences in rats are potentiated by peripherally administered alprazolam. | lld:pubmed |
| pubmed-article:16297973 | pubmed:affiliation | Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106, United States. | lld:pubmed |
| pubmed-article:16297973 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16297973 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16297973 | lld:pubmed |
