| pubmed-article:16293763 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16293763 | lifeskim:mentions | umls-concept:C1171348 | lld:lifeskim |
| pubmed-article:16293763 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:16293763 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16293763 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16293763 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:16293763 | pubmed:issue | 5751 | lld:pubmed |
| pubmed-article:16293763 | pubmed:dateCreated | 2005-11-18 | lld:pubmed |
| pubmed-article:16293763 | pubmed:abstractText | The immunological synapse is a specialized cell-cell junction that is defined by large-scale spatial patterns of receptors and signaling molecules yet remains largely enigmatic in terms of formation and function. We used supported bilayer membranes and nanometer-scale structures fabricated onto the underlying substrate to impose geometric constraints on immunological synapse formation. Analysis of the resulting alternatively patterned synapses revealed a causal relation between the radial position of T cell receptors (TCRs) and signaling activity, with prolonged signaling from TCR microclusters that had been mechanically trapped in the peripheral regions of the synapse. These results are consistent with a model of the synapse in which spatial translocation of TCRs represents a direct mechanism of signal regulation. | lld:pubmed |
| pubmed-article:16293763 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16293763 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16293763 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16293763 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16293763 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16293763 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16293763 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16293763 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16293763 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:16293763 | pubmed:author | pubmed-author:DustinMichael... | lld:pubmed |
| pubmed-article:16293763 | pubmed:author | pubmed-author:GrovesJay TJT | lld:pubmed |
| pubmed-article:16293763 | pubmed:author | pubmed-author:CampiGabriele... | lld:pubmed |
| pubmed-article:16293763 | pubmed:author | pubmed-author:MossmanKaspar... | lld:pubmed |
| pubmed-article:16293763 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16293763 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:16293763 | pubmed:volume | 310 | lld:pubmed |
| pubmed-article:16293763 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16293763 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16293763 | pubmed:pagination | 1191-3 | lld:pubmed |
| pubmed-article:16293763 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16293763 | pubmed:meshHeading | pubmed-meshheading:16293763... | lld:pubmed |
| pubmed-article:16293763 | pubmed:meshHeading | pubmed-meshheading:16293763... | lld:pubmed |
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| pubmed-article:16293763 | pubmed:meshHeading | pubmed-meshheading:16293763... | lld:pubmed |
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| pubmed-article:16293763 | pubmed:meshHeading | pubmed-meshheading:16293763... | lld:pubmed |
| pubmed-article:16293763 | pubmed:meshHeading | pubmed-meshheading:16293763... | lld:pubmed |
| pubmed-article:16293763 | pubmed:meshHeading | pubmed-meshheading:16293763... | lld:pubmed |
| pubmed-article:16293763 | pubmed:meshHeading | pubmed-meshheading:16293763... | lld:pubmed |
| pubmed-article:16293763 | pubmed:meshHeading | pubmed-meshheading:16293763... | lld:pubmed |
| pubmed-article:16293763 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16293763 | pubmed:articleTitle | Altered TCR signaling from geometrically repatterned immunological synapses. | lld:pubmed |
| pubmed-article:16293763 | pubmed:affiliation | Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA. | lld:pubmed |
| pubmed-article:16293763 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16293763 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16293763 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16293763 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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