| pubmed-article:16291717 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16291717 | lifeskim:mentions | umls-concept:C0009905 | lld:lifeskim |
| pubmed-article:16291717 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16291717 | lifeskim:mentions | umls-concept:C0444706 | lld:lifeskim |
| pubmed-article:16291717 | lifeskim:mentions | umls-concept:C0243102 | lld:lifeskim |
| pubmed-article:16291717 | lifeskim:mentions | umls-concept:C0678420 | lld:lifeskim |
| pubmed-article:16291717 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16291717 | pubmed:dateCreated | 2005-11-18 | lld:pubmed |
| pubmed-article:16291717 | pubmed:abstractText | The effects of a common oral contraceptive preparation on the activity of 7 drug-metabolizing enzymes were investigated using the validated Cooperstown 5+1 Cocktail. In a randomized crossover fashion, 10 premenopausal women received caffeine, dextromethorphan, omeprazole, intravenous midazolam, and warfarin + vitamin K with and without a triphasic oral contraceptive (ethinyl estradiol 35 microg) and varying doses of daily norgestimate (0.18, 0.215, and 0.25 mg). Bioequivalence testing showed nonequivalence in drug versus no-drug treatment on the activity of drug-metabolizing enzymes (as reflected by metabolite ratios following probe drug administration); the activity of CYP1A2, CYP2C19, and NAT-2 decreased following the oral contraceptive, whereas the activity of CYP2C9 and CYP2D6 increased. No effects on xanthine oxidase or hepatic CYP3A were seen. Application of a non-parametric statistical testing approach revealed a significant difference only for CYP1A2 and CYP2C19. This triphasic oral contraceptive may have a clinically significant effect on the activity of some drug-metabolizing enzymes. | lld:pubmed |
| pubmed-article:16291717 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16291717 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16291717 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16291717 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16291717 | pubmed:issn | 0091-2700 | lld:pubmed |
| pubmed-article:16291717 | pubmed:author | pubmed-author:BertinoJoseph... | lld:pubmed |
| pubmed-article:16291717 | pubmed:author | pubmed-author:NafzigerAnne... | lld:pubmed |
| pubmed-article:16291717 | pubmed:author | pubmed-author:KashubaAngela... | lld:pubmed |
| pubmed-article:16291717 | pubmed:author | pubmed-author:LeederJ... | lld:pubmed |
| pubmed-article:16291717 | pubmed:author | pubmed-author:GaedigkAndrea... | lld:pubmed |
| pubmed-article:16291717 | pubmed:author | pubmed-author:ZhangYanhuaY | lld:pubmed |
| pubmed-article:16291717 | pubmed:author | pubmed-author:SellersEdward... | lld:pubmed |
| pubmed-article:16291717 | pubmed:author | pubmed-author:RowlandElizab... | lld:pubmed |
| pubmed-article:16291717 | pubmed:author | pubmed-author:VictoryJennif... | lld:pubmed |
| pubmed-article:16291717 | pubmed:author | pubmed-author:ShelepovaTati... | lld:pubmed |
| pubmed-article:16291717 | pubmed:author | pubmed-author:KearnsGregory... | lld:pubmed |
| pubmed-article:16291717 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16291717 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:16291717 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16291717 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16291717 | pubmed:pagination | 1413-21 | lld:pubmed |
| pubmed-article:16291717 | pubmed:dateRevised | 2010-9-8 | lld:pubmed |
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| pubmed-article:16291717 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16291717 | pubmed:articleTitle | Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail. | lld:pubmed |
| pubmed-article:16291717 | pubmed:affiliation | Department of Medicine, Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York, USA. | lld:pubmed |
| pubmed-article:16291717 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16291717 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16291717 | lld:pubmed |
