| pubmed-article:16288983 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16288983 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:16288983 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:16288983 | lifeskim:mentions | umls-concept:C1442521 | lld:lifeskim |
| pubmed-article:16288983 | lifeskim:mentions | umls-concept:C0249197 | lld:lifeskim |
| pubmed-article:16288983 | lifeskim:mentions | umls-concept:C1426212 | lld:lifeskim |
| pubmed-article:16288983 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16288983 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16288983 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:16288983 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16288983 | pubmed:dateCreated | 2005-11-23 | lld:pubmed |
| pubmed-article:16288983 | pubmed:abstractText | The precise role of IL-6 in liver regeneration and hepatocyte proliferation is controversial and the role of SOCS3 in liver regeneration remains unknown. Here we show that in vitro treatment with IL-6 inhibited primary mouse hepatocyte proliferation. IL-6 induced p21cip1 protein expression in primary mouse hepatocytes. Disruption of the p21cip1 gene abolished the inhibitory effect of IL-6 on cell proliferation. Co-culture with nonparenchymal liver cells diminished IL-6 inhibition of hepatocyte proliferation, which was likely due to IL-6 stimulation of nonparenchymal cells to produce HGF. Finally, IL-6 induced higher levels of p21cip1 protein expression and a slightly stronger inhibition of cell proliferation in SOCS3+/- mouse hepatocytes compared to wild-type hepatocytes, while liver regeneration was enhanced and prolonged in SOCS3+/- mice. Our findings suggest that IL-6 directly inhibits hepatocyte proliferation via a p21cip1-dependent mechanism and indirectly enhances hepatocyte proliferation via stimulating nonparenchymal cells to produce HGF. SOCS3 negatively regulates liver regeneration. | lld:pubmed |
| pubmed-article:16288983 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16288983 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288983 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16288983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16288983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16288983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288983 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16288983 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16288983 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:16288983 | pubmed:author | pubmed-author:LeeS KSK | lld:pubmed |
| pubmed-article:16288983 | pubmed:author | pubmed-author:LiuMinM | lld:pubmed |
| pubmed-article:16288983 | pubmed:author | pubmed-author:JarugaBarbara... | lld:pubmed |
| pubmed-article:16288983 | pubmed:author | pubmed-author:KulkarniShail... | lld:pubmed |
| pubmed-article:16288983 | pubmed:author | pubmed-author:SunHaoyuH | lld:pubmed |
| pubmed-article:16288983 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16288983 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:16288983 | pubmed:volume | 338 | lld:pubmed |
| pubmed-article:16288983 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16288983 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16288983 | pubmed:pagination | 1943-9 | lld:pubmed |
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| pubmed-article:16288983 | pubmed:meshHeading | pubmed-meshheading:16288983... | lld:pubmed |
| pubmed-article:16288983 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16288983 | pubmed:articleTitle | IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: regulation by SOCS3. | lld:pubmed |
| pubmed-article:16288983 | pubmed:affiliation | Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:16288983 | pubmed:publicationType | Journal Article | lld:pubmed |
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