| pubmed-article:16288226 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16288226 | lifeskim:mentions | umls-concept:C0282636 | lld:lifeskim |
| pubmed-article:16288226 | lifeskim:mentions | umls-concept:C0023749 | lld:lifeskim |
| pubmed-article:16288226 | lifeskim:mentions | umls-concept:C0287592 | lld:lifeskim |
| pubmed-article:16288226 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:16288226 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:16288226 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:16288226 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:16288226 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:16288226 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16288226 | pubmed:dateCreated | 2006-2-23 | lld:pubmed |
| pubmed-article:16288226 | pubmed:abstractText | Peroxisome proliferator-activated receptors (PPARs) are transcription factors that strongly influence molecular events in normal and cancer cells. PPAR-beta/delta (PPAR-b/d) overexpression suppresses the activity of PPAR-gamma (PPAR-g) and PPAR-alpha. This interaction has been questioned, however, by studies with synthetic ligands of PPARs in PPAR-b/d-null cells, and it is not known whether an interaction between PPAR-b/d and PPAR-g exists, especially in relation to the signaling by natural PPAR ligands. Oxidative metabolites of linoleic and arachidonic acids are natural ligands of PPARs. 13-S-hydroxyoctadecadienoic acid (13-S-HODE), the main product of 15-lipoxygenase-1 (15-LOX-1) metabolism of linoleic acid, downregulates PPAR-b/d. We tested (a) whether PPAR-b/d expression modulates PPAR-g activity in experimental models of the loss and gain of PPAR-b/d function in colon cancer cells and (b) whether 15-LOX-1 formation of 13-S-HODE influences the interaction between PPAR-b/d and PPAR-g. We found that (a) 15-LOX-1 formation of 13-S-HODE promoted PPAR-g activity, (b) PPAR-b/d expression suppressed PPAR-g activity in models of both loss and gain of PPAR-b/d function, (c) 15-LOX-1 activated PPAR-g by downregulating PPAR-b/d, and (d) 15-LOX-1 expression induced apoptosis in colon cancer cells via modulating PPAR-b/d suppression of PPAR-g. These findings elucidate a novel mechanism of the signaling by natural ligands of PPARs, which involves modulating the interaction between PPAR-b/d and PPAR-g. | lld:pubmed |
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| pubmed-article:16288226 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16288226 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16288226 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16288226 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16288226 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:16288226 | pubmed:author | pubmed-author:ZubKK | lld:pubmed |
| pubmed-article:16288226 | pubmed:author | pubmed-author:WuYY | lld:pubmed |
| pubmed-article:16288226 | pubmed:author | pubmed-author:FischerS MSM | lld:pubmed |
| pubmed-article:16288226 | pubmed:author | pubmed-author:MorrisJ SJS | lld:pubmed |
| pubmed-article:16288226 | pubmed:author | pubmed-author:LippmanS MSM | lld:pubmed |
| pubmed-article:16288226 | pubmed:author | pubmed-author:StimmelJ BJB | lld:pubmed |
| pubmed-article:16288226 | pubmed:author | pubmed-author:LeesnitzerL... | lld:pubmed |
| pubmed-article:16288226 | pubmed:author | pubmed-author:ShureiqiII | lld:pubmed |
| pubmed-article:16288226 | pubmed:copyrightInfo | Oncogene (2006) 25, 1225-1241. doi:10.1038/sj.onc.1209160; published online 14 November 2005. | lld:pubmed |
| pubmed-article:16288226 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16288226 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:16288226 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:16288226 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16288226 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16288226 | pubmed:pagination | 1225-41 | lld:pubmed |
| pubmed-article:16288226 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:16288226 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16288226 | pubmed:articleTitle | Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. | lld:pubmed |
| pubmed-article:16288226 | pubmed:affiliation | Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77230-1439, USA. | lld:pubmed |
| pubmed-article:16288226 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16288226 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16288226 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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