| pubmed-article:16286018 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16286018 | lifeskim:mentions | umls-concept:C0282114 | lld:lifeskim |
| pubmed-article:16286018 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:16286018 | lifeskim:mentions | umls-concept:C0699040 | lld:lifeskim |
| pubmed-article:16286018 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:16286018 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:16286018 | lifeskim:mentions | umls-concept:C0023636 | lld:lifeskim |
| pubmed-article:16286018 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16286018 | pubmed:dateCreated | 2005-11-15 | lld:pubmed |
| pubmed-article:16286018 | pubmed:abstractText | Dendritic cells process internalized antigens to present degradative products on MHC for TCR recognition. Because antigen-exposed DCs also induce humoral immunity, DCs must also retain antigen in its native state for the engagement of BCR on B cells. Here, we demonstrate that antigen endocytosed by the inhibitory Fc receptor, FcgammaRIIB, accesses a non-degradative intracellular vesicular compartment that recycles to the cell surface, enabling interaction of native antigen with BCR on B cells. Immunization with IgG-opsonized, T independent antigens leads to enhanced humoral responses in a FcgammaRIIB and complement dependent manner. IC-loaded DCs trafficking to the splenic marginal zone can prime a T independent response in an FcgammaRIIB-dependent manner. Thus dendritic cells are equipped with both non-degradative and degradative antigen uptake pathways to facilitate antigen presentation to both B and T cells. | lld:pubmed |
| pubmed-article:16286018 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286018 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286018 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286018 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16286018 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286018 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16286018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16286018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286018 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16286018 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16286018 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:16286018 | pubmed:author | pubmed-author:BergtoldAmyA | lld:pubmed |
| pubmed-article:16286018 | pubmed:author | pubmed-author:ClynesRaphael... | lld:pubmed |
| pubmed-article:16286018 | pubmed:author | pubmed-author:DesaiDharmesh... | lld:pubmed |
| pubmed-article:16286018 | pubmed:author | pubmed-author:GavhaneAnamik... | lld:pubmed |
| pubmed-article:16286018 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16286018 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:16286018 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16286018 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16286018 | pubmed:pagination | 503-14 | lld:pubmed |
| pubmed-article:16286018 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16286018 | pubmed:meshHeading | pubmed-meshheading:16286018... | lld:pubmed |
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| pubmed-article:16286018 | pubmed:meshHeading | pubmed-meshheading:16286018... | lld:pubmed |
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| pubmed-article:16286018 | pubmed:meshHeading | pubmed-meshheading:16286018... | lld:pubmed |
| pubmed-article:16286018 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16286018 | pubmed:articleTitle | Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. | lld:pubmed |
| pubmed-article:16286018 | pubmed:affiliation | Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. | lld:pubmed |
| pubmed-article:16286018 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16286018 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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