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pubmed-article:16284469pubmed:abstractTextThe structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts the niche and limits the size of the resident CD4 cell population. In this report we show that a single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the peripheral CD4 cell pool with HAART (P < 0.001). This suggests that collagen-targeted therapies might be of benefit.lld:pubmed
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pubmed-article:16284469pubmed:articleTitleAmount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count.lld:pubmed
pubmed-article:16284469pubmed:affiliationDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.lld:pubmed
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