| pubmed-article:16284267 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16284267 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:16284267 | lifeskim:mentions | umls-concept:C0020202 | lld:lifeskim |
| pubmed-article:16284267 | lifeskim:mentions | umls-concept:C0028606 | lld:lifeskim |
| pubmed-article:16284267 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:16284267 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:16284267 | lifeskim:mentions | umls-concept:C0679932 | lld:lifeskim |
| pubmed-article:16284267 | lifeskim:mentions | umls-concept:C1552961 | lld:lifeskim |
| pubmed-article:16284267 | lifeskim:mentions | umls-concept:C0150312 | lld:lifeskim |
| pubmed-article:16284267 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16284267 | pubmed:dateCreated | 2006-1-13 | lld:pubmed |
| pubmed-article:16284267 | pubmed:abstractText | Microarray analysis has become increasingly complex due to the growing size of arrays and the inherent cross-binding of targets. In this work, we explore the effects of matched and mismatched target species concentrations, temperature, and the time of hybridization on sensing specificity in two-component systems. A finite element software is used to simulate the diffusion of DNA through a microfluidic chamber to the sensing surface where hybridization of DNA is modeled using the corresponding kinetic equation. Comparison between a single-component system, where only one target is allowed to bind to a specific zone, and a two-component system, where more than one target can hybridize in a sensing zone, uncovers significant kinetic disparities during the transitory state; however, at thermodynamic equilibrium a modified Langmuir isotherm governs the bound amount of both species. The results presented suggest that it may be more appropriate to consider collective rather than quasi-independent interaction of targets in multicomponent systems. | lld:pubmed |
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| pubmed-article:16284267 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16284267 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16284267 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16284267 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16284267 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16284267 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:16284267 | pubmed:author | pubmed-author:BlaisRR | lld:pubmed |
| pubmed-article:16284267 | pubmed:author | pubmed-author:BishopJJ | lld:pubmed |
| pubmed-article:16284267 | pubmed:author | pubmed-author:ChagovetzA... | lld:pubmed |
| pubmed-article:16284267 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16284267 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16284267 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:16284267 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16284267 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16284267 | pubmed:pagination | 831-40 | lld:pubmed |
| pubmed-article:16284267 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16284267 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16284267 | pubmed:articleTitle | A competitive kinetic model of nucleic acid surface hybridization in the presence of point mutants. | lld:pubmed |
| pubmed-article:16284267 | pubmed:affiliation | Department of Electrical and Computer Engineering University of Utah, Salt Lake City, Utah, USA. | lld:pubmed |
| pubmed-article:16284267 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16284267 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:16284267 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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