| pubmed-article:16283570 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16283570 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16283570 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:16283570 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:16283570 | lifeskim:mentions | umls-concept:C0004368 | lld:lifeskim |
| pubmed-article:16283570 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:16283570 | lifeskim:mentions | umls-concept:C1718423 | lld:lifeskim |
| pubmed-article:16283570 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:16283570 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:16283570 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:16283570 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:16283570 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16283570 | pubmed:dateCreated | 2005-12-5 | lld:pubmed |
| pubmed-article:16283570 | pubmed:abstractText | Cytotoxic T lymphocyte-associated antigen (CTLA)-4 can inhibit T-cell responses and is involved in tolerance against self antigens. We previously reported autoimmune manifestations and objective cancer regressions in patients with metastatic melanoma treated with CTLA-4 blockade. The possibility of activating tumor-reactive T cells while removing inhibitory activity with CTLA-4 blockade has stimulated interest in using anti-CTLA-4 antibodies in combination with other cancer immunotherapies to improve clinical outcomes. In this study, we assessed the antitumor activity and autoimmune toxicity of CTLA-4 blockade in combination with an immune-activating stimulus, interleukin (IL)-2, in patients with metastatic melanoma. | lld:pubmed |
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| pubmed-article:16283570 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16283570 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16283570 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16283570 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16283570 | pubmed:issn | 1068-9265 | lld:pubmed |
| pubmed-article:16283570 | pubmed:author | pubmed-author:SherryRichard... | lld:pubmed |
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| pubmed-article:16283570 | pubmed:author | pubmed-author:YangJames CJC | lld:pubmed |
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| pubmed-article:16283570 | pubmed:author | pubmed-author:KleinerDavidD | lld:pubmed |
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| pubmed-article:16283570 | pubmed:author | pubmed-author:MakerAjay VAV | lld:pubmed |
| pubmed-article:16283570 | pubmed:author | pubmed-author:LevyCatherine... | lld:pubmed |
| pubmed-article:16283570 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16283570 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:16283570 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16283570 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16283570 | pubmed:pagination | 1005-16 | lld:pubmed |
| pubmed-article:16283570 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:16283570 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16283570 | pubmed:articleTitle | Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. | lld:pubmed |
| pubmed-article:16283570 | pubmed:affiliation | Surgery Branch, National Cancer Institute, National Institutes of Health, CRC Room 3-3940, 10 Center Drive, MSC 1201, Bethesda, MD 20814, USA. | lld:pubmed |
| pubmed-article:16283570 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16283570 | pubmed:publicationType | Clinical Trial, Phase II | lld:pubmed |
| pubmed-article:16283570 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
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