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pubmed-article:16275384pubmed:abstractTextRegulatory T cells have been proposed to play an important role in regulating allergic inflammation. The transcription factor Foxp3 is a master switch gene that controls the development and function of natural and adaptive CD4(+)CD25(+) regulatory T (T(R)) cells. In human subjects loss-of-function Foxp3 mutations trigger lymphoproliferation, autoimmunity, and intense allergic inflammation in a disease termed immune dysregulation polyendocrinopathy enteropathy-X-linked syndrome.lld:pubmed
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pubmed-article:16275384pubmed:articleTitleAllergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice.lld:pubmed
pubmed-article:16275384pubmed:affiliationDivision of Immunology, Allergy and Rheumatology, Department of Pediatrics, The David Geffen School of Medicine at the University of California at Los Angeles, MDCC 12-430, 10833 Le Conte Ave, Los Angeles, CA 90095-1752, USA.lld:pubmed
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