| pubmed-article:16273209 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16273209 | lifeskim:mentions | umls-concept:C0042172 | lld:lifeskim |
| pubmed-article:16273209 | lifeskim:mentions | umls-concept:C0007137 | lld:lifeskim |
| pubmed-article:16273209 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:16273209 | lifeskim:mentions | umls-concept:C0178874 | lld:lifeskim |
| pubmed-article:16273209 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16273209 | lifeskim:mentions | umls-concept:C1419993 | lld:lifeskim |
| pubmed-article:16273209 | lifeskim:mentions | umls-concept:C1420069 | lld:lifeskim |
| pubmed-article:16273209 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16273209 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16273209 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16273209 | pubmed:dateCreated | 2005-11-7 | lld:pubmed |
| pubmed-article:16273209 | pubmed:abstractText | Loss of E-cadherin expression allows carcinoma cells to liberate from the primary site and enhances invasion and metastasis. The genetic aberration of E-cadherin is a rare event in sporadic carcinomas, and transcription repressors are considered to take a central role in E-cadherin loss. However, expression of E-cadherin repressors is largely dependent on tissue and cell type. To identify the repressor expressed in oral squamous carcinomas, we compared the expression levels of E-cadherin and repressors by real-time RT-PCR. Among the repressors including SNAIL, SLUG, SIP1, E12 and E47, SIP1 was inversely correlated to E-cadherin (P < 0.05). Chromatin immunoprecipitation showed that SIP1 specifically bound to the E-cadherin promoter region. SIP1 expression was immuno-histochemically detected in 27.7% of 47 oral carcinomas, and SIP1-positive carcinomas did not express E-cadherin (P < 0.01). Thirteen patients with SIP1 staining showed a lower disease-specific survival rate (P < 0.05). Multivariate risk factor analysis demonstrated that SIP1 expression was an independent prognostic value for disease-specific overall survival (P < 0.05). These results suggest that SIP1 contributes to the loss of E-cadherin expression and that detection of SIP1 expression is a predictive and prognostic tool in clinical management of oral carcinomas. | lld:pubmed |
| pubmed-article:16273209 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16273209 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16273209 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16273209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16273209 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16273209 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16273209 | pubmed:issn | 1019-6439 | lld:pubmed |
| pubmed-article:16273209 | pubmed:author | pubmed-author:ImaiKazushiK | lld:pubmed |
| pubmed-article:16273209 | pubmed:author | pubmed-author:OkazakiMasahi... | lld:pubmed |
| pubmed-article:16273209 | pubmed:author | pubmed-author:AobaTakaakiT | lld:pubmed |
| pubmed-article:16273209 | pubmed:author | pubmed-author:KawashiriShui... | lld:pubmed |
| pubmed-article:16273209 | pubmed:author | pubmed-author:KatoKorokuK | lld:pubmed |
| pubmed-article:16273209 | pubmed:author | pubmed-author:TayaYujiY | lld:pubmed |
| pubmed-article:16273209 | pubmed:author | pubmed-author:SatohTazukoT | lld:pubmed |
| pubmed-article:16273209 | pubmed:author | pubmed-author:ChibaTadashig... | lld:pubmed |
| pubmed-article:16273209 | pubmed:author | pubmed-author:MaedaGentaG | lld:pubmed |
| pubmed-article:16273209 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16273209 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:16273209 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16273209 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16273209 | pubmed:pagination | 1535-41 | lld:pubmed |
| pubmed-article:16273209 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16273209 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16273209 | pubmed:articleTitle | Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression. | lld:pubmed |
| pubmed-article:16273209 | pubmed:affiliation | Department of Biochemistry, School of Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan. | lld:pubmed |
| pubmed-article:16273209 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16273209 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16273209 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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