| pubmed-article:16271083 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C1384551 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C0476089 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C0972212 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C0205282 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C0665341 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C0449258 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C1335813 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C1421638 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C1511741 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16271083 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16271083 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16271083 | pubmed:dateCreated | 2005-11-7 | lld:pubmed |
| pubmed-article:16271083 | pubmed:abstractText | 14-3-3 sigma (sigma) is a negative regulator of the cell cycle and contributes to G2 arrest. Lack of its expression due to hypermethylation of CpG islands has been reported in some carcinomas. A recent study showed that 14-3-3 sigma was down-regulated through proteolysis by estrogen-responsive finger protein (Efp). Here, we investigated the expression of 14-3-3 sigma, hormone receptors, Efp and p53 in 86 cases of endometrial adenocarcinoma and 46 cases of normal or non-neoplastic endometria by means of immunohistochemistry and methylation-specific polymerase chain reaction. In normal endometrium, 14-3-3 sigma was overexpressed in the mid- to late-secretory phase due to hypomethylation. In endometrial adenocarcinoma, 14-3-3 sigma expression was low in low grade endometrioid adenocarcinoma due to hypermethylation, and increased significantly with increasing histological grade due to hypomethylation. 14-3-3 sigma expression inversely correlated with estrogen receptor alpha, progesterone receptor and Efp, and positively correlated with myometrial invasion and lymph node metastasis. These results suggest that 14-3-3 sigma was one of the menstrual cycle-related proteins regulated by epigenetic methylation, and its expression was influenced by epigenetic methylation or hormone receptors in progression of endometrial adenocarcinoma, and therefore was more than just a cell-cycle regulator. | lld:pubmed |
| pubmed-article:16271083 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16271083 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271083 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16271083 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16271083 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16271083 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16271083 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16271083 | pubmed:issn | 1320-5463 | lld:pubmed |
| pubmed-article:16271083 | pubmed:author | pubmed-author:OyamaTetsunar... | lld:pubmed |
| pubmed-article:16271083 | pubmed:author | pubmed-author:SanoTakaakiT | lld:pubmed |
| pubmed-article:16271083 | pubmed:author | pubmed-author:NakajimaTakas... | lld:pubmed |
| pubmed-article:16271083 | pubmed:author | pubmed-author:MotegiAtsushi... | lld:pubmed |
| pubmed-article:16271083 | pubmed:author | pubmed-author:NakayamaHirok... | lld:pubmed |
| pubmed-article:16271083 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16271083 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:16271083 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16271083 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16271083 | pubmed:pagination | 707-15 | lld:pubmed |
| pubmed-article:16271083 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:16271083 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16271083 | pubmed:articleTitle | Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma. | lld:pubmed |
| pubmed-article:16271083 | pubmed:affiliation | Department of Tumor Pathology, Gunma University, Graduate School of Medicine, Faculty of Medicine, Maebashi, Japan. hnakayam@med.gunma-u.ac.jp | lld:pubmed |
| pubmed-article:16271083 | pubmed:publicationType | Journal Article | lld:pubmed |
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