| pubmed-article:16267136 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16267136 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:16267136 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16267136 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:16267136 | lifeskim:mentions | umls-concept:C0029453 | lld:lifeskim |
| pubmed-article:16267136 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:16267136 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16267136 | lifeskim:mentions | umls-concept:C1709366 | lld:lifeskim |
| pubmed-article:16267136 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:16267136 | pubmed:issue | 46 | lld:pubmed |
| pubmed-article:16267136 | pubmed:dateCreated | 2005-11-18 | lld:pubmed |
| pubmed-article:16267136 | pubmed:abstractText | The bone wasting induced by estrogen deficiency is, in part, a consequence of increased T cell production of the osteoclastogenic cytokine TNF-alpha. This phenomenon is due to an expansion of T cells, but the responsible mechanism is unknown. We now show that ovariectomy (ovx) disregulates T lymphopoiesis and induces bone loss by stimulating, through a rise in IL-7 levels, both thymic-dependent differentiation of bone marrow-derived progenitors and thymic-independent, peripheral expansion of mature T cells. Attesting to the relevance of the thymic effects, thymectomy decreases by approximately 50% the bone loss and the stimulation of T lymphopoiesis induced by ovx. In contrast, in vivo attenuation of the elevated IL-7 completely prevents the stimulation of T lymphopoiesis and the bone loss that follow ovx. Thus, the disruption of both T cell and bone homeostasis induced by ovx is mediated by IL-7 and due to both the thymic and extrathymic mechanisms. We conclude that IL-7 is a pivotal upstream target through which estrogen regulates hematopoietic and immune functions that are critical for bone homeostasis. | lld:pubmed |
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| pubmed-article:16267136 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16267136 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16267136 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16267136 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16267136 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16267136 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:16267136 | pubmed:author | pubmed-author:SchnellFreder... | lld:pubmed |
| pubmed-article:16267136 | pubmed:author | pubmed-author:KershGilbert... | lld:pubmed |
| pubmed-article:16267136 | pubmed:author | pubmed-author:GrassiFrances... | lld:pubmed |
| pubmed-article:16267136 | pubmed:author | pubmed-author:WeitzmannM... | lld:pubmed |
| pubmed-article:16267136 | pubmed:author | pubmed-author:PacificiRober... | lld:pubmed |
| pubmed-article:16267136 | pubmed:author | pubmed-author:QianWei-PingW... | lld:pubmed |
| pubmed-article:16267136 | pubmed:author | pubmed-author:LeaveyJennife... | lld:pubmed |
| pubmed-article:16267136 | pubmed:author | pubmed-author:GaoYuhaoY | lld:pubmed |
| pubmed-article:16267136 | pubmed:author | pubmed-author:ShepherdRebec... | lld:pubmed |
| pubmed-article:16267136 | pubmed:author | pubmed-author:RyanMichaela... | lld:pubmed |
| pubmed-article:16267136 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16267136 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16267136 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:16267136 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16267136 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16267136 | pubmed:pagination | 16735-40 | lld:pubmed |
| pubmed-article:16267136 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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