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pubmed-article:16266747pubmed:abstractTextThis study was conducted to examine the effects of neonatal maternal separation on the hypothalamic expression of feeding peptides in later life. Pups in maternal separation (MS) groups were separated from their dam for 3 h daily from postnatal day (PND) 1-14, while pups in non-handled (NH) groups were left undisturbed. Rats were sacrificed on PND 60 to examine the gene expression of neuropeptide Y (NPY) and pro-opiomelanocortin (POMC) in the hypothalamic arcuate nucleus by mRNA in situ hybridization. Half of the rats from each group were food-deprived for 48 h before sacrifice. POMC mRNA expression increased in the free fed MS group compared with the free fed NH group. Food deprivation significantly decreased the arcuate POMC mRNA level in both groups. Body weight gain, basal levels of plasma corticosterone, leptin, and arcuate NPY mRNA were not modulated by experience of neonatal maternal separation. However, fasting-induced increases of plasma corticosterone and arcuate NPY expression were blunted in MS rats. These results suggest that neonatal maternal separation may increase the basal expression level of arcuate POMC mRNA, while inhibit the fasting-induced expression of arcuate NPY mRNA, later in life. Lastly, the altered expression of arcuate NPY mRNA, but not of arcuate POMC mRNA, appeared to be related with altered activity of the hypothalamic-pituitary-adrenal gland axis in offspring by neonatal maternal separation.lld:pubmed
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pubmed-article:16266747pubmed:authorpubmed-author:LeeJ HJHlld:pubmed
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pubmed-article:16266747pubmed:pagination587-94lld:pubmed
pubmed-article:16266747pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16266747pubmed:articleTitleFasting-induced increases of arcuate NPY mRNA and plasma corticosterone are blunted in the rat experienced neonatal maternal separation.lld:pubmed
pubmed-article:16266747pubmed:affiliationDepartment of Pharmacology, BK21 Project for Medical Science, Yonsei University College of Medicine, Shin Chon Dong, Seo Dae Moon Ku, Seoul, Republic of Korea.lld:pubmed
pubmed-article:16266747pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16266747pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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