| pubmed-article:16264196 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16264196 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16264196 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:16264196 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16264196 | lifeskim:mentions | umls-concept:C1326960 | lld:lifeskim |
| pubmed-article:16264196 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:16264196 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16264196 | pubmed:dateCreated | 2006-1-26 | lld:pubmed |
| pubmed-article:16264196 | pubmed:abstractText | As previously reported by us, mice with targeted disruption of the CYP8B1 gene (CYP8B1-/-) fail to produce cholic acid (CA), upregulate their bile acid synthesis, reduce the absorption of dietary cholesterol and, after cholesterol feeding, accumulate less liver cholesterol than wild-type (CYP8B1+/+) mice. In the present study, cholesterol-enriched diet (0.5%) or administration of a synthetic liver X receptor (LXR) agonist strongly upregulated CYP7A1 expression in CYP8B1-/- mice, compared to CYP8B1+/+ mice. Cholesterol-fed CYP8B1-/- mice also showed a significant rise in HDL cholesterol and increased levels of liver ABCA1 mRNA. A combined CA (0.25%)/cholesterol (0.5%) diet enhanced absorption of intestinal cholesterol in both groups of mice, increased their liver cholesterol content, and reduced their expression of CYP7A1 mRNA. The ABCG5/G8 liver mRNA was increased in both groups of mice, but cholesterol crystals were only observed in bile from the CYP8B1+/+ mice. The results demonstrate the cholesterol-sparing effects of CA: enhanced absorption and reduced conversion into bile acids. Farnesoid X receptor (FXR)-mediated suppression of CYP7A1 in mice seems to be a predominant mechanism for regulation of bile acid synthesis under normal conditions and, as confirmed, able to override LXR-mediated mechanisms. Interaction between FXR- and LXR-mediated stimuli might also regulate expression of liver ABCG5/G8. | lld:pubmed |
| pubmed-article:16264196 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16264196 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16264196 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16264196 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16264196 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16264196 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16264196 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16264196 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16264196 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16264196 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16264196 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16264196 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16264196 | pubmed:issn | 0022-2275 | lld:pubmed |
| pubmed-article:16264196 | pubmed:author | pubmed-author:BjörkhemII | lld:pubmed |
| pubmed-article:16264196 | pubmed:author | pubmed-author:WangJJ | lld:pubmed |
| pubmed-article:16264196 | pubmed:author | pubmed-author:MurphyCC | lld:pubmed |
| pubmed-article:16264196 | pubmed:author | pubmed-author:PariniPP | lld:pubmed |
| pubmed-article:16264196 | pubmed:author | pubmed-author:GåfvelsMM | lld:pubmed |
| pubmed-article:16264196 | pubmed:author | pubmed-author:EggertsenGG | lld:pubmed |
| pubmed-article:16264196 | pubmed:author | pubmed-author:EinarssonCC | lld:pubmed |
| pubmed-article:16264196 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16264196 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:16264196 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16264196 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16264196 | pubmed:pagination | 421-30 | lld:pubmed |
| pubmed-article:16264196 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16264196 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16264196 | pubmed:articleTitle | Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice. | lld:pubmed |
| pubmed-article:16264196 | pubmed:affiliation | Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden. | lld:pubmed |
| pubmed-article:16264196 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16264196 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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