| pubmed-article:16263504 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16263504 | lifeskim:mentions | umls-concept:C1527116 | lld:lifeskim |
| pubmed-article:16263504 | lifeskim:mentions | umls-concept:C1556095 | lld:lifeskim |
| pubmed-article:16263504 | lifeskim:mentions | umls-concept:C0108082 | lld:lifeskim |
| pubmed-article:16263504 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:16263504 | lifeskim:mentions | umls-concept:C0002564 | lld:lifeskim |
| pubmed-article:16263504 | lifeskim:mentions | umls-concept:C0023175 | lld:lifeskim |
| pubmed-article:16263504 | lifeskim:mentions | umls-concept:C0041980 | lld:lifeskim |
| pubmed-article:16263504 | lifeskim:mentions | umls-concept:C0132555 | lld:lifeskim |
| pubmed-article:16263504 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:16263504 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:16263504 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16263504 | pubmed:dateCreated | 2005-11-2 | lld:pubmed |
| pubmed-article:16263504 | pubmed:abstractText | Recent research suggests that uric acid may be nephrotoxic at lower levels than previously recognized and that it may be one mechanism for lead-related nephrotoxicity. Therefore, in understanding mechanisms for lead-related nephrotoxicity, it would be of value to determine whether genetic polymorphisms that are associated with renal outcomes in lead workers and/or modify associations between lead dose and renal function are also associated with uric acid and/or modify associations between lead dose and uric acid. We analyzed data on three such genetic polymorphisms: delta-aminolevulinic acid dehydratase (ALAD), endothelial nitric oxide synthase (eNOS), and the vitamin D receptor (VDR). Mean (+/- SD) tibia, blood, and dimercaptosuccinic acid-chelatable lead levels were 37.2 +/- 40.4 microg/g bone mineral, 32.0+/- 15.0 g/dL, and 0.77+/- 0.86 microg/mg creatinine, respectively, in 798 current and former lead workers. Participants with the eNOSAsp allele had lower mean serum uric acid compared with those with the Glu/Glu genotype. Among older workers (age > or = median of 40.6 years), ALAD genotype modified associations between lead dose and uric acid levels. Higher lead dose was significantly associated with higher uric acid in workers with the ALAD1-1 genotype; associations were in the opposite direction in participants with the variant ALAD1-2 genotype. In contrast, higher tibia lead was associated with higher uric acid in those with the variant VDRB allele; however, modification was dependent on participants with the bb genotype and high tibia lead levels. We conclude that genetic polymorphisms may modify uric acid mediation of lead-related adverse renal effects. | lld:pubmed |
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| pubmed-article:16263504 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16263504 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16263504 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16263504 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16263504 | pubmed:issn | 0091-6765 | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:KelseyKarl... | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:LeeByung-Kook... | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:SchwartzBrian... | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:ToddAndrew... | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:ParsonsPatric... | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:SilbergeldEll... | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:JaarBernard... | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:LeeSung-SooSS | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:WeaverVirgini... | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:AhnKyu-DongKD | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:WenJiayuJ | lld:pubmed |
| pubmed-article:16263504 | pubmed:author | pubmed-author:LustbergMark... | lld:pubmed |
| pubmed-article:16263504 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16263504 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:16263504 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16263504 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16263504 | pubmed:pagination | 1509-15 | lld:pubmed |
| pubmed-article:16263504 | pubmed:dateRevised | 2011-9-27 | lld:pubmed |
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