| pubmed-article:16263332 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16263332 | lifeskim:mentions | umls-concept:C1412056 | lld:lifeskim |
| pubmed-article:16263332 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:16263332 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:16263332 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16263332 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:16263332 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:16263332 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:16263332 | lifeskim:mentions | umls-concept:C0282580 | lld:lifeskim |
| pubmed-article:16263332 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:16263332 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:16263332 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16263332 | pubmed:dateCreated | 2005-11-21 | lld:pubmed |
| pubmed-article:16263332 | pubmed:abstractText | Adeno-associated virus has been developed for use as a gene transfer vector. To understand the impact of AAV capsid-specific CD8(+) T cells on AAV-mediated gene transfer, we identified CD8(+) T cell epitopes for AAV-2 and AAV-8 capsid in C57BL/6 (H-2(b) MHC haplotype) and BALB/c (H-2(d) MHC haplotype) mice. Mice of both the H-2(b) and the H-2(d) haplotypes recognized epitopes on AAV-2 and AAV-8 capsid. T cells from H-2(b) mice recognized an epitope that was conserved between AAV-2 and AAV-8 capsid. Cross-reactivity of AAV-specific CD8(+) T cells induced by different AAV serotypes may have important implications for gene transfer. Identification of these epitopes will facilitate studies of immune response to AAV capsid in mouse models. | lld:pubmed |
| pubmed-article:16263332 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16263332 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16263332 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16263332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16263332 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16263332 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16263332 | pubmed:issn | 1525-0016 | lld:pubmed |
| pubmed-article:16263332 | pubmed:author | pubmed-author:ErtlHildegund... | lld:pubmed |
| pubmed-article:16263332 | pubmed:author | pubmed-author:ColosiPeterP | lld:pubmed |
| pubmed-article:16263332 | pubmed:author | pubmed-author:HighKatherine... | lld:pubmed |
| pubmed-article:16263332 | pubmed:author | pubmed-author:SabatinoDenis... | lld:pubmed |
| pubmed-article:16263332 | pubmed:author | pubmed-author:MingozziFeder... | lld:pubmed |
| pubmed-article:16263332 | pubmed:author | pubmed-author:ChenHaifengH | lld:pubmed |
| pubmed-article:16263332 | pubmed:author | pubmed-author:HuiDaniel JDJ | lld:pubmed |
| pubmed-article:16263332 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16263332 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:16263332 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16263332 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16263332 | pubmed:pagination | 1023-33 | lld:pubmed |
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| pubmed-article:16263332 | pubmed:meshHeading | pubmed-meshheading:16263332... | lld:pubmed |
| pubmed-article:16263332 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16263332 | pubmed:articleTitle | Identification of mouse AAV capsid-specific CD8+ T cell epitopes. | lld:pubmed |
| pubmed-article:16263332 | pubmed:affiliation | The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. | lld:pubmed |
| pubmed-article:16263332 | pubmed:publicationType | Journal Article | lld:pubmed |
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