| pubmed-article:16261419 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16261419 | lifeskim:mentions | umls-concept:C0008109 | lld:lifeskim |
| pubmed-article:16261419 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:16261419 | lifeskim:mentions | umls-concept:C0085243 | lld:lifeskim |
| pubmed-article:16261419 | lifeskim:mentions | umls-concept:C1265498 | lld:lifeskim |
| pubmed-article:16261419 | lifeskim:mentions | umls-concept:C0596508 | lld:lifeskim |
| pubmed-article:16261419 | lifeskim:mentions | umls-concept:C0008670 | lld:lifeskim |
| pubmed-article:16261419 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:16261419 | lifeskim:mentions | umls-concept:C0751781 | lld:lifeskim |
| pubmed-article:16261419 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:16261419 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:16261419 | pubmed:dateCreated | 2005-11-1 | lld:pubmed |
| pubmed-article:16261419 | pubmed:abstractText | Penetrance of the complex of genes predisposing the nonobese diabetic (NOD) mouse to autoimmune diabetes is affected by the maternal environment. NOD.CBALs-Tyr(+)/Lt is an agouti-pigmented Chromosome 7 congenic stock of NOD/Lt mice produced as a resource for embryo transfer experiments to provide the necessary maternal factors and allow the easy identification of NOD (albino) embryo donor phenotype. CBcNO6/Lt, a recombinant congenic agouti stock already containing approximately 50% NOD genome, was used as the donor source of a wild-type CBA tyrosinase allele. When the incidence of diabetes was assessed after nine generations of backcrossing and one generation of sib-sib mating, significant reduction in diabetes development was observed. No difference in diabetes development was observed in Tyr/Tyr(c) heterozygotes, showing that protection was recessive. Analysis of diabetes progression in another NOD stock congenic for C57BL/6 alleles on Chromosome 7 linked to the glucose phosphate isomerase (Gpi1(b)) locus provided no protection, indicating that the diabetes resistance (Idd) gene was distal to 34 cM (D7Mit346). Approximately 5 cM of the distal congenic region overlaps a region from C57L previously associated with protection when homozygous. The delayed onset and reduced frequency of diabetes in the NOD.CBALs-Tyr(+)/Lt stock is an advantage when females of this stock are used as surrogate mothers in studies involving hysterectomy or embryo transfers. Indeed, a newly developed NOD embryonic stem (ES) cell line injected into NOD.CBALs- Tyr(+)/Lt blastocysts produced approximately 50% live-born mice, of which approximately 11% were chimeric. Presumably because of high genomic instability, no germline transmission was observed. | lld:pubmed |
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| pubmed-article:16261419 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16261419 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16261419 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16261419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16261419 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16261419 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16261419 | pubmed:issn | 0938-8990 | lld:pubmed |
| pubmed-article:16261419 | pubmed:author | pubmed-author:ChenJingJ | lld:pubmed |
| pubmed-article:16261419 | pubmed:author | pubmed-author:NagyAndrasA | lld:pubmed |
| pubmed-article:16261419 | pubmed:author | pubmed-author:Koch-NolteFri... | lld:pubmed |
| pubmed-article:16261419 | pubmed:author | pubmed-author:ReifsnyderPet... | lld:pubmed |
| pubmed-article:16261419 | pubmed:author | pubmed-author:LeiterEdward... | lld:pubmed |
| pubmed-article:16261419 | pubmed:author | pubmed-author:EllisJamesJ | lld:pubmed |
| pubmed-article:16261419 | pubmed:author | pubmed-author:ScheupleinFel... | lld:pubmed |
| pubmed-article:16261419 | pubmed:author | pubmed-author:MileikovskyMa... | lld:pubmed |
| pubmed-article:16261419 | pubmed:author | pubmed-author:SchottWilliam... | lld:pubmed |
| pubmed-article:16261419 | pubmed:author | pubmed-author:Soodeen-Karam... | lld:pubmed |
| pubmed-article:16261419 | pubmed:author | pubmed-author:DoschMichael... | lld:pubmed |
| pubmed-article:16261419 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16261419 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:16261419 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16261419 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16261419 | pubmed:pagination | 775-83 | lld:pubmed |
| pubmed-article:16261419 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:16261419 | pubmed:meshHeading | pubmed-meshheading:16261419... | lld:pubmed |
| pubmed-article:16261419 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16261419 | pubmed:articleTitle | "Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. | lld:pubmed |
| pubmed-article:16261419 | pubmed:affiliation | The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609-1500, USA. | lld:pubmed |
| pubmed-article:16261419 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16261419 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16261419 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16261419 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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