| pubmed-article:16251423 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16251423 | lifeskim:mentions | umls-concept:C0005847 | lld:lifeskim |
| pubmed-article:16251423 | lifeskim:mentions | umls-concept:C0699893 | lld:lifeskim |
| pubmed-article:16251423 | lifeskim:mentions | umls-concept:C0148199 | lld:lifeskim |
| pubmed-article:16251423 | lifeskim:mentions | umls-concept:C0030946 | lld:lifeskim |
| pubmed-article:16251423 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:16251423 | lifeskim:mentions | umls-concept:C0684321 | lld:lifeskim |
| pubmed-article:16251423 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:16251423 | lifeskim:mentions | umls-concept:C1882115 | lld:lifeskim |
| pubmed-article:16251423 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:16251423 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16251423 | pubmed:dateCreated | 2005-10-27 | lld:pubmed |
| pubmed-article:16251423 | pubmed:abstractText | Vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis, and blockade of VEGF receptor 2 (VEGFR-2), with the monoclonal antibody DC101, inhibits angiogenesis and tumor growth. To examine the short-term effects of DC101, we surface transplanted the squamous cell carcinoma cell line A5-RT3 onto nude mice. After short-term treatment with DC101, we observed rapid reduction in vascularization and reversion of the tumor phenotype. Beginning 24 hours after treatment, VEGFR-2 inhibition resulted in decreased vessel density within the tenascin-c-staining tumor-associated stroma and reduced endothelial cell proliferation. Stromal expression of matrix metalloproteinase-9 and -13 was drastically reduced 96 hours after VEGFR-2 inhibition as detected by in situ hybridization and in situ zymography. Moreover, the morphology of the tumor-stroma border changed from a highly invasive carcinoma to a well-demarcated, premalignant phenotype. The latter was characterized by the appearance of a regular basement membrane in immunostaining and ultrastructural analyses. These findings suggest that VEGFR-2 inhibition by DC101 evokes very rapid reduction of preformed vessels and decreases both stromal protease expression and gelatinolytic activity, resulting in the modulation of the tumor-stroma border zone and reversion of the tumor phenotype. Thus, short-term inhibition of VEGF signaling results in complex stromal alterations with crucial consequences for the tumor phenotype. | lld:pubmed |
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| pubmed-article:16251423 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16251423 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16251423 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16251423 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16251423 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16251423 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:16251423 | pubmed:author | pubmed-author:BohlenPeterP | lld:pubmed |
| pubmed-article:16251423 | pubmed:author | pubmed-author:HicklinDaniel... | lld:pubmed |
| pubmed-article:16251423 | pubmed:author | pubmed-author:HolzFrank GFG | lld:pubmed |
| pubmed-article:16251423 | pubmed:author | pubmed-author:FusenigNorber... | lld:pubmed |
| pubmed-article:16251423 | pubmed:author | pubmed-author:VölckerHans... | lld:pubmed |
| pubmed-article:16251423 | pubmed:author | pubmed-author:VosselerSilvi... | lld:pubmed |
| pubmed-article:16251423 | pubmed:author | pubmed-author:MillerDaniel... | lld:pubmed |
| pubmed-article:16251423 | pubmed:author | pubmed-author:MiranceaNicol... | lld:pubmed |
| pubmed-article:16251423 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16251423 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:16251423 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16251423 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16251423 | pubmed:pagination | 1389-403 | lld:pubmed |
| pubmed-article:16251423 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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