| pubmed-article:16242163 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16242163 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:16242163 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:16242163 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:16242163 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:16242163 | lifeskim:mentions | umls-concept:C2348480 | lld:lifeskim |
| pubmed-article:16242163 | lifeskim:mentions | umls-concept:C0005197 | lld:lifeskim |
| pubmed-article:16242163 | lifeskim:mentions | umls-concept:C0062124 | lld:lifeskim |
| pubmed-article:16242163 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16242163 | pubmed:dateCreated | 2006-2-6 | lld:pubmed |
| pubmed-article:16242163 | pubmed:abstractText | The endogenous beta-carboline, harmane, has been shown to bind to monoamine oxidase A (MAO-A) and a separate, high affinity, non-MAO site. Research in our laboratory has shown that harmane is an active component of clonidine-displacing substance (CDS), the proposed endogenous ligand for imidazoline binding sites (IBS). In the present study we have investigated the distribution of [3H]harmane in rat brain, and related the binding profile to the distribution of the MAO-A selective ligand [3H]Ro41-1049 and the I2BS ligand [3H]2-BFI. The in vivo distribution of [3H]harmane following intravenous administration was also investigated. Receptor autoradiography revealed a highly significant correlation for the distribution of [3H]harmane and [3H]Ro41-1049, and a significant correlation for [3H]harmane and the I2BS ligand [3H]2-BFI. The in vivo distribution of [3H]harmane suggests that the ligand accumulates in the adrenal gland and throughout the brain with the primary route of excretion occurring via the duodenum. In conclusion, these studies have shown that [3H]harmane labels a population of binding sites that reflect the distribution of MAO-A. Further evidence for a non-MAO, IBS [3H]harmane population has not been shown but the high level of expression of the MAO-A site is likely to have masked the much smaller population of I2BS. | lld:pubmed |
| pubmed-article:16242163 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16242163 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16242163 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16242163 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16242163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16242163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16242163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16242163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16242163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16242163 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16242163 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16242163 | pubmed:issn | 0028-3908 | lld:pubmed |
| pubmed-article:16242163 | pubmed:author | pubmed-author:HusbandsSteph... | lld:pubmed |
| pubmed-article:16242163 | pubmed:author | pubmed-author:NuttDavid JDJ | lld:pubmed |
| pubmed-article:16242163 | pubmed:author | pubmed-author:TyackeRobin... | lld:pubmed |
| pubmed-article:16242163 | pubmed:author | pubmed-author:RobinsonEmma... | lld:pubmed |
| pubmed-article:16242163 | pubmed:author | pubmed-author:HudsonAlan... | lld:pubmed |
| pubmed-article:16242163 | pubmed:author | pubmed-author:AndersonNeil... | lld:pubmed |
| pubmed-article:16242163 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16242163 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:16242163 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16242163 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16242163 | pubmed:pagination | 269-76 | lld:pubmed |
| pubmed-article:16242163 | pubmed:dateRevised | 2007-8-13 | lld:pubmed |
| pubmed-article:16242163 | pubmed:meshHeading | pubmed-meshheading:16242163... | lld:pubmed |
| pubmed-article:16242163 | pubmed:meshHeading | pubmed-meshheading:16242163... | lld:pubmed |
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| pubmed-article:16242163 | pubmed:meshHeading | pubmed-meshheading:16242163... | lld:pubmed |
| pubmed-article:16242163 | pubmed:meshHeading | pubmed-meshheading:16242163... | lld:pubmed |
| pubmed-article:16242163 | pubmed:meshHeading | pubmed-meshheading:16242163... | lld:pubmed |
| pubmed-article:16242163 | pubmed:meshHeading | pubmed-meshheading:16242163... | lld:pubmed |
| pubmed-article:16242163 | pubmed:meshHeading | pubmed-meshheading:16242163... | lld:pubmed |
| pubmed-article:16242163 | pubmed:meshHeading | pubmed-meshheading:16242163... | lld:pubmed |
| pubmed-article:16242163 | pubmed:meshHeading | pubmed-meshheading:16242163... | lld:pubmed |
| pubmed-article:16242163 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16242163 | pubmed:articleTitle | In vitro and ex vivo distribution of [3H]harmane, an endogenous beta-carboline, in rat brain. | lld:pubmed |
| pubmed-article:16242163 | pubmed:affiliation | Department of Pharmacology, School of Medical Sciences, University Walk, Clifton, Bristol, BS8 1TD, UK. | lld:pubmed |
| pubmed-article:16242163 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16242163 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16242163 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:16242163 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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